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DMAB-anabaseine dihydrochloride

Cat. No. 2241

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Chemical Name: 4-[(5,6-Dihydro[2,3'-bipyridin]-3(4H)-ylidene)methyl]-N,N-dimethylbenzenamine dihydrochloride

Biological Activity

Partial agonist at α7-containing neuronal nicotinic receptors and antagonist at α4β2 and other nicotinic receptors. Displays specific cognition-enhancing effects; improves long-term memory in rats.

Technical Data

M.Wt:

364.32

Formula:

C₁₉H₂₁N₃.2HCl

Solubility:

Soluble to 100 mM in water and to 25 mM in DMSO

Purity:

>98 %

Storage:

Desiccate at -20°C

CAS No:

32013-69-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Arendash et al (1995) Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21. Brain Res. 674 252. PMID: 7796104.

Kem et al (1997) Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. J.Pharmacol.Exp.Ther. 283 979. PMID: 9399967.

Stevens et al (1998) Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice. Psychopharmacology 136 320. PMID: 9600576.

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Keywords: DMAB-anabaseine dihydrochloride, supplier, Partial, agonists, α7, alpha7-containing, a7, receptors, antagonists, α4β2, a4b2, neuronal, nicotinic, Nicotinic, Receptors, Acetylcholine, nAChR