GW 583340 dihydrochloride
Cat. No. 2239
Chemical Name: N-[3-Chloro-4-[(3-fluorophenyl)meth
Biological ActivityPotent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50 values are 0.01 and 0.014 μM respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC50 values are 0.11 μM for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μM for inhibition of non-tumor cell line HFF). Inhibits tumor growth in vivo by ~ 80% in a murine xenograft model following oral administration.
Licensing InformationSold for research purposes under agreement from GlaxoSmithKline.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Gaul et al (2003) Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines. Bioorg.Med.Chem.Lett. 13 637. PMID: 12639547.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: GW 583340 dihydrochloride, supplier, Potent, dual, EGFR, ErbB2, inhibitors, orally, active, Epidermal, Growth, Factors, Receptors, Her, Receptor, Tyrosine, Kinases, RTKs, GW583340, dihydrochloride, GlaxoSmithKline, GSK
Find multiple products by catalog number
New Products in this Area
PDX1 transcription factor inducer; increases insulin expressionKRCA 0008
Potent Ack1 and ALK dual inhibitor; orally bioavailableDDR1-IN-1 dihydrochloride
Selective DDR1 inhibitorPLX 647 dihydrochloride
Potent dual Fms/KIT inhibitor
July 23 - 27, 2014
Bonn University, Germany