R&D Systems Inc. Tocris Bioscience Boston Biochem

GW 441756

Cat. No. 2238

GW 441756 C17H13N3O [504433-23-2]

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Chemical Name: 1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one

Biological Activity

Potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM). Displays > 100-fold selectivity over a range of other kinases.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data

M.Wt:
275.31
Formula:
C17H13N3O
Solubility:
Soluble to 15 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
504433-23-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Wood et al (2004) Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg.Med.Chem.Lett. 14 953. PMID: 15013000.

If you know of a relevant citation for this product please let us know.

Keywords: GW 441756, supplier, Potent, selective, TrkA, inhibitors, Neurotrophin, Receptors, Receptor, Tyrosine, Kinases, RTKs, GW441756, GlaxoSmithKline, GSK

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