GW 441756

Cat. No. 2238

GW 441756 C17H13N3O [504433-23-2]

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Chemical Name: 1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one

Biological Activity

Potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM). Displays > 100-fold selectivity over a range of other kinases.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data

M.Wt:
275.31
Formula:
C17H13N3O
Solubility:
Soluble to 15 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
504433-23-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Wood et al (2004) Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg.Med.Chem.Lett. 14 953. PMID: 15013000.

If you know of a relevant citation for this product please let us know.

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Keywords: GW 441756, supplier, Potent, selective, TrkA, inhibitors, Neurotrophin, Receptors, Receptor, Tyrosine, Kinases, RTKs, GW441756, GlaxoSmithKline, GSK, Tocris Bioscience, Trk Receptor Inhibitors

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