Cat. No. 2238
Chemical Name: 1,3-Dihydro-3-[(1-methyl-1H-indol-3
Biological ActivityPotent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM). Displays > 100-fold selectivity over a range of other kinases.
Licensing InformationSold for research purposes under agreement from GlaxoSmithKline.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Wood et al (2004) Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg.Med.Chem.Lett. 14 953. PMID: 15013000.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: GW 441756, supplier, Potent, selective, TrkA, inhibitors, Neurotrophin, Receptors, Receptor, Tyrosine, Kinases, RTKs, GW441756, GlaxoSmithKline, GSK
Find multiple products by catalog number
New Products in this Area
Potent c-MET/ALK inhibitorAC 710
Potent and selective PDGFR family inhibitorSPP 86
Potent RET inhibitorSGX 523
Selective and potent c-MET kinase inhibitorNBI 31772
High affinity insulin-like growth factor-I binding protein IGFBP inhibitorAPcK 110
Highly potent HGF/c-MET inhibitor; also AT4 antagonistAEE 788
Potent EGFR and VEGFR inhibitorXL 184
Potent VEGFR inhibitor; also inhibits other RTKsPKI 166 hydrochloride
Potent EGFR-kinase inhibitor
July 4 - 9, 2015