R&D Systems Inc. Tocris Bioscience Boston Biochem

N1,N11-Diethylnorspermine tetrahydrochloride

Cat. No. 0468

N1,N11-Diethylnorspermine tetrahydrochloride C13H32N4.4HCl [156886-85-0]

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Chemical Name: N,N'-bis[3-(Ethylamino)propyl]-1,3-propanediamine tetrahydrochloride

Biological Activity

Highly potent inducer of spermidine/spermine N1-acetyltransferase, able to increase enzyme activity 200-1000 fold.

Technical Data

M.Wt:
390.27
Formula:
C13H32N4.4HCl
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
156886-85-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Libby et al (1991) Characterization of human spermidine spermine N1-acetyltransferase purified from cultured melanoma cells. Arch.Biochem.Biophys. 284 238. PMID: 1989509.

Bernacki et al (1992) Antitumour activity of N1,N12-bis(ethyl)spermine homologs against human MALME-3 melanoma xenografts. Cancer Res. 52 2424. PMID: 1568212.

Porter et al (1993) Antitumour activity of N1,N12-bis(ethyl)-norspermine against human melanoma xenografts and possible biochemical correlates of drug action. Cancer Res. 53 581. PMID: 8425191.

Fogel-Petrovic et al (1997) Structural basis for differential induction of spermidine/spermine N1-acetyltransferase activity by novel spermine analogs. Mol.Pharmacol. 52 69. PMID: 9224814.

If you know of a relevant citation for this product please let us know.

Keywords: N1,N11-Diethylnorspermine tetrahydrochloride, supplier, Spermine, spermidine, N1-acetyltransferase, potentiator, Acyltransferases, Transferases

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