Cat. No. 0468
Chemical Name: N,N'-bis[3-(Ethylamino)propyl]-1,3-p
Biological ActivityHighly potent inducer of spermidine/spermine N1-acetyltransferase, able to increase enzyme activity 200-1000 fold.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Libby et al (1991) Characterization of human spermidine spermine N1-acetyltransferase purified from cultured melanoma cells. Arch.Biochem.Biophys. 284 238. PMID: 1989509.
Bernacki et al (1992) Antitumour activity of N1,N12-bis(ethyl)spermine homologs against human MALME-3 melanoma xenografts. Cancer Res. 52 2424. PMID: 1568212.
Porter et al (1993) Antitumour activity of N1,N12-bis(ethyl)-norspermine against human melanoma xenografts and possible biochemical correlates of drug action. Cancer Res. 53 581. PMID: 8425191.
Fogel-Petrovic et al (1997) Structural basis for differential induction of spermidine/spermine N1-acetyltransferase activity by novel spermine analogs. Mol.Pharmacol. 52 69. PMID: 9224814.
If you know of a relevant citation for this product please let us know.
Keywords: N1,N11-Diethylnorspermine tetrahydrochloride, supplier, Spermine, spermidine, N1-acetyltransferase, potentiator, Acyltransferases, Transferases
Find multiple products by catalog number
New Products in this Area
Used to solubilize and denature proteinsTricine
Electrophoresis bufferSodium phosphate monobasic
Commonly used in biological assay buffersPonceau S Staining Solution
Stain used to detect protein bands after Western blottingMTT
Reagent used in the measurement of cell proliferationHematoxylin
Dye used to stain cell nucleiGuanidine Hydrochloride
Widely used in sample buffer preparationBromophenol Blue
Dye used in gel loading buffersBovine Serum Albumin
Widely used blocking agent for ELISA and blottingBIS-TRIS
Commonly used buffering agentBoric acid
Widely used in buffers for electrophoresisSodium dodecyl sulphate solution
Detergent used in electrophoresis of proteinsPolyoxyethylenesorbitan monolaurate
Detergent used for protein extractionDulbecco's PBS
Buffered saline used in mammalian cell cultureSodium phosphate dibasic
Commonly used in biological assay buffersPotassium phosphate monobasic
Commonly used in biological assay buffersAbK
Photo-crosslinking probePropidium iodide
Red-fluorescent DNA stain; membrane impermeant to live cellsCongo Red
Amyloid fibril binding dye; also a VGlut inhibitor
November 15 - 19, 2014
Washington D.C., USA