N1,N11-Diethylnorspermine tetrahydrochloride

Cat. No. 0468

N1,N11-Diethylnorspermine tetrahydrochloride C13H32N4.4HCl [156886-85-0]

Price and Availability

For N1,N11-Diethylnorspermine tetrahydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N,N'-bis[3-(Ethylamino)propyl]-1,3-propanediamine tetrahydrochloride

Biological Activity

Highly potent inducer of spermidine/spermine N1-acetyltransferase, able to increase enzyme activity 200-1000 fold.

Technical Data

M.Wt:
390.27
Formula:
C13H32N4.4HCl
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
156886-85-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Libby et al (1991) Characterization of human spermidine spermine N1-acetyltransferase purified from cultured melanoma cells. Arch.Biochem.Biophys. 284 238. PMID: 1989509.

Bernacki et al (1992) Antitumour activity of N1,N12-bis(ethyl)spermine homologs against human MALME-3 melanoma xenografts. Cancer Res. 52 2424. PMID: 1568212.

Porter et al (1993) Antitumour activity of N1,N12-bis(ethyl)-norspermine against human melanoma xenografts and possible biochemical correlates of drug action. Cancer Res. 53 581. PMID: 8425191.

Fogel-Petrovic et al (1997) Structural basis for differential induction of spermidine/spermine N1-acetyltransferase activity by novel spermine analogs. Mol.Pharmacol. 52 69. PMID: 9224814.

If you know of a relevant citation for this product please let us know.

View Related Products by Product Action

Keywords: N1,N11-Diethylnorspermine tetrahydrochloride, supplier, Spermine, spermidine, N1-acetyltransferase, potentiator, Acyltransferases, Transferases, Tocris Bioscience, Other Transferases

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

NPG

Highlights 130 new products added in the first half of 2015. View PDF today.

divider line

New Products in this Area

G 28UCM

FASN inhibitor

Sign-up for new product e-alerts
divider line

AACR 2016

Win a $1,000 travel grant

AACR Travel Grant

Bio-Techne is offering 10 travel grants of $1,000 for AACR 2016.