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N1,N11-Diethylnorspermine tetrahydrochlorideCat. No. 0468 |
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Chemical Name: N,N'-bis[3-(Ethylamino)propyl]-1,3-propanediamine tetrahydrochloride |
Biological Activity
Highly potent inducer of spermidine/spermine N1-acetyltransferase, able to increase enzyme activity 200-1000 fold.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
References
Libby et al (1991) Characterization of human spermidine spermine N1-acetyltransferase purified from cultured melanoma cells. Arch.Biochem.Biophys. 284 238. PMID: 1989509.
Bernacki et al (1992) Antitumour activity of N1,N12-bis(ethyl)spermine homologs against human MALME-3 melanoma xenografts. Cancer Res. 52 2424. PMID: 1568212.
Porter et al (1993) Antitumour activity of N1,N12-bis(ethyl)-norspermine against human melanoma xenografts and possible biochemical correlates of drug action. Cancer Res. 53 581. PMID: 8425191.
Fogel-Petrovic et al (1997) Structural basis for differential induction of spermidine/spermine N1-acetyltransferase activity by novel spermine analogs. Mol.Pharmacol. 52 69. PMID: 9224814.
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Keywords: N1,N11-Diethylnorspermine tetrahydrochloride, supplier, Spermine, spermidine, N1-acetyltransferase, potentiator, Acyltransferases, Transferases
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