CI 976

Cat. No. 2227

CI 976 C23H39NO4 [114289-47-3]

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Chemical Name: 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide

Biological Activity

Selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.073 μM). Lowers non-high density lipoprotein (HDL)-cholesterol and increases HDL-cholesterol concentrations in rats with pre-established dyslipidemia. Orally active. Also inhibits Golgi-associated LPL acyltransferase (LPAT) activity (IC50 = 15 μM).

Technical Data

M.Wt:
393.57
Formula:
C23H39NO4
Solubility:
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
114289-47-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Sliskovic and White (1991) Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents. TiPS. 12 194.

Krause et al (1993) In vivo evidence that the lipid-regulating activity of ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT. J.Lipid Res. 34 279. PMID: 8429262.

Drecktrah et al (2003) Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking. Mol.Biol.Cell 14 3549.

If you know of a relevant citation for this product please let us know.

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Keywords: CI 976, supplier, Acyl-CoAcholesterol, acyltransferase, ACAT, inhibitors, Transferases, CI976

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