Cat. No. 2227
Chemical Name: 2,2-Dimethyl-N-(2,4,6-trimethoxyphe
Biological ActivitySelective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.073 μM). Lowers non-high density lipoprotein (HDL)-cholesterol and increases HDL-cholesterol concentrations in rats with pre-established dyslipidemia. Orally active. Also inhibits Golgi-associated LPL acyltransferase (LPAT) activity (IC50 = 15 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Sliskovic and White (1991) Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents. TiPS. 12 194.
Krause et al (1993) In vivo evidence that the lipid-regulating activity of ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT. J.Lipid Res. 34 279. PMID: 8429262.
Drecktrah et al (2003) Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking. Mol.Biol.Cell 14 3549.
If you know of a relevant citation for this product please let us know.
Keywords: CI 976, supplier, Acyl-CoAcholesterol, acyltransferase, ACAT, inhibitors, Transferases, CI976
Find multiple products by catalog number
New Products in this Area
High affinity and selective WDR5 antagonistMM 102
WDR5/MLL interaction inhibitorCRID3 sodium salt
Glutathione S-transferase omega 1 (GSTO1) inhibitorUNC 2327
Allosteric inhibitor of PRMT3Furamidine dihydrochloride
Selective PRMT1 inhibitorXY1
Negative control of SGC 707 (Cat. No. 5367)SGC 707
Potent and selective allosteric inhibitor of PRMT3IWP 12
Potent PORCN inhibitor; active in vivoAZD 3988
Potent and selective diacylglycerol acyltransferase 1 (DGAT-1) inhibitorWDR5 0103
WDR5 antagonistUNC 2400
Negative control of UNC 1999 (Cat. No. 4904)UNC 1999
Potent and selective EZH2/EZH1 inhibitorGarcinol
PCAF/p300 inhibitor; anticancer(S)-PFI 2 hydrochloride
Negative control of (R)-PFI 2 hydrochloride (Cat. No. 4892)
September 5 - 8, 2015