R&D Systems Inc. Tocris Bioscience Boston Biochem

PDZ1 Domain inhibitor peptide

Cat. No. 2207

PDZ1 Domain inhibitor peptide Tyr-Lys-cyclo(-Lys-Thr-Glu-β-Ala-)-Val

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Biological Activity

Novel cyclic peptide that disrupts interaction between GluR6 and the postsynaptic density protein 95 (PSD-95). Competes with the C-terminus of GluR6 for binding to the PDZ1 domain of PSD-95. Inhibits clustering of kainate receptors.

Technical Data

M.Wt:
819.95
Formula:
C38H61N9O11
Sequence:
YKKTEAV

(Modifications: Ala-6 = β-Ala, Cyclized = Lys-3 - Ala-6))

Solubility:
Soluble to 1 mg/ml in 5% acetonitrile / water and to 4 mg/ml in DMSO
Storage:
Desiccate at -20°C
CAS No:
1315378-73-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Piserchio et al (2004) Targeting specific PDZ domains of PSD-95: structural basis for enhanced affinity and enzymatic stability of a cyclic peptide. Chem.Biol. 11 469. PMID: 15123241.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: PDZ1 Domain inhibitor peptide, supplier, Disrupts, interaction, between, GluR6, PSD-95, PDZ1, domain, Glutamate, Kainate, Receptors, iGluR, Ionotropic

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