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PALDA

Cat. No. 2203

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Alternative Name: N-Palmitoyldopamine

Chemical Name: N-[2-(3,4-Dihydroxyphenyl)ethyl]hexadecanamide

Biological Activity

Endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB₁ receptors (at concentrations up to 5 μM) and does not inhibit AMT or FAAH (IC₅₀ > 25 μM). However, potentiates TRPV1-mediated effects of NADA; lowers EC₅₀ from ~ 90 to ~ 30 nM.

Technical Data

M.Wt:

391.59

Formula:

C₂₄H₄₁NO₃

Solubility:

Soluble to 5 mM in ethanol with gentle warming

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

136181-87-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Chu et al (2003) N-Oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J.Biol.Chem. 278 13633. PMID: 12569099.

De Petrocellis et al (2004) Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels. Br.J.Pharmacol. 143 251. PMID: 15289293.

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