R&D Systems Inc. Tocris Bioscience Boston Biochem

PALDA

Cat. No. 2203

PALDA C24H41NO3 [136181-87-8]

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Alternative Name: N-Palmitoyldopamine

Chemical Name: N-[2-(3,4-Dihydroxyphenyl)ethyl]hexadecanamide

Biological Activity

Endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB1 receptors (at concentrations up to 5 μM) and does not inhibit AMT or FAAH (IC50 > 25 μM). However, potentiates TRPV1-mediated effects of NADA; lowers EC50 from ~ 90 to ~ 30 nM.

Technical Data

M.Wt:
391.59
Formula:
C24H41NO3
Solubility:
Soluble to 5 mM in ethanol with gentle warming
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
136181-87-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Chu et al (2003) N-Oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J.Biol.Chem. 278 13633. PMID: 12569099.

De Petrocellis et al (2004) Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels. Br.J.Pharmacol. 143 251. PMID: 15289293.

If you know of a relevant citation for this product please let us know.

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Keywords: PALDA, supplier, Endogenous, lipid, potentiates, effects, endovanilloids, TRPV1, receptors, Vanillioid, Receptors, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential

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