R&D Systems Inc. Tocris Bioscience Boston Biochem

Proglumide sodium salt

Cat. No. 1478

Proglumide sodium salt C18H25N2NaO4 [99247-33-3]

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Chemical Name: 4-(Benzoylamino)-5-(dipropylamino)-­5-oxopentanoic acid sodium salt

Biological Activity

Non-selective cholecystokinin (CCK) antagonist. Inhibits CCK-stimulated amylase secretion and prevents CCK-induced 2-deoxyglucose uptake in mouse pancreatic acini. Blocks growth of HT29 colon carcinoma cells in response to gastrin 17 treatment. Orally active.

Technical Data

M.Wt:
356.39
Formula:
C18H25N2NaO4
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
99247-33-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Hahne et al (1981) Proglumide and benzotript: members of a different class of cholecystokinin receptor antagonists. Proc.Natl.Acad.Sci.U.S.A. 78 6304. PMID: 6171817.

Iwamoto et al (1984) In vitro and in vivo effect of proglumide on cholecystokinin-stimulated amylase release in mouse pancreatic acini. Gastroenterol.Jpn. 19 53. PMID: 6202584.

Mauss et al (1994) Effects of gastrin, proglumide, loxiglumide and L-365,260 on growth of human colon carcinoma cells. Anticancer Res. 14 215. PMID: 8166452.

If you know of a relevant citation for this product please let us know.

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