R&D Systems Inc. Tocris Bioscience Boston Biochem

SQ 22536

Cat. No. 1435

SQ 22536 C9H11N5O [17318-31-9]

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Chemical Name: 9-(Tetrahydro-2-furanyl)-9H-purin-6-amine

Biological Activity

Inhibitor of adenylyl cyclase (IC50 = 1.4 μM). Inhibits PGE1-stimulated increases in cAMP levels in intact human platelets.

Technical Data

M.Wt:
205.22
Formula:
C9H11N5O
Solubility:
Soluble to 50 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
17318-31-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Harris et al (1979) Inhibition of adenylate cyclase in human blood platelets by 9-substituted adenine derivatives. J.Cyclic Nucleotide Res. 5 125. PMID: 221552.

Fabbri et al (1991) Inhibition of adenylate cyclase of catfish and rat hepatocyte membranes by 9-(tetrahydro-2-furyl)adenine (SQ 22536). J.Enzyme Inhib. 5 87. PMID: 1669444.

Hourani et al (2001) Role of cyclic nucleotides in vasodilations of the rat thoracic aorta induced by adenosine analogues. Br.J.Pharmacol. 133 833. PMID: 11454656.

If you know of a relevant citation for this product please let us know.

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Keywords: SQ 22536, supplier, Adenylyl, cyclase, inhibitors, Cyclases, adenylate, SQ22536

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