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SQ 22536Cat. No. 1435 |
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Chemical Name: 9-(Tetrahydro-2-furanyl)-9H-purin-6-amine |
Biological Activity
Inhibitor of adenylyl cyclase (IC50 = 1.4 μM). Inhibits PGE1-stimulated increases in cAMP levels in intact human platelets.Certificate of Analysis / Safety Data Sheet
References
Harris et al (1979) Inhibition of adenylate cyclase in human blood platelets by 9-substituted adenine derivatives. J.Cyclic Nucleotide Res. 5 125. PMID: 221552.
Fabbri et al (1991) Inhibition of adenylate cyclase of catfish and rat hepatocyte membranes by 9-(tetrahydro-2-furyl)adenine (SQ 22536). J.Enzyme Inhib. 5 87. PMID: 1669444.
Hourani et al (2001) Role of cyclic nucleotides in vasodilations of the rat thoracic aorta induced by adenosine analogues. Br.J.Pharmacol. 133 833. PMID: 11454656.
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Keywords: SQ 22536, supplier, Adenylyl, cyclase, inhibitors, Cyclases, adenylate, SQ22536
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