MDL 12330A hydrochloride

Cat. No. 1436

MDL 12330A hydrochloride C23H36N2.HCl [40297-09-4]

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Chemical Name: (±)-N-[(1R*,2R*)-2-Phenylcyclopentyl]-azacyclotridec-1-en-2-amine hydrochloride

Biological Activity

Inhibitor of adenylyl cyclase. Also inhibits cAMP and cGMP phosphodiesterases, and blocks slow extracellular and store-operated Ca2+ entry into cells.

Technical Data

Soluble to 20 mM in DMSO and to 20 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Guellaen et al (1977) RMI 12330 A, an inhibitor of adenylate cyclase in rat liver. Biochim.Biophys.Acta 484 465. PMID: 911855.

Hunt and Evans (1980) RMI 12330A, an inhibitor of cyclic nucleotide phosphodiesterases and adenylate cyclase in kidney preparations. Biochim.Biophys.Acta 613 499. PMID: 6256001.

van Rossum et al (2000) Ca2+ entry mediated by store depletion, S-nitrosylation, and TRP3 channels. Comparison of coupling and function. J.Biol.Chem. 275 28562. PMID: 10878007.

If you know of a relevant citation for this product please let us know.

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Keywords: MDL 12330A hydrochloride, supplier, adenylyl, cyclase, cyclic, AMP, GMP, cAMP, cGMP, PDE, phosphodiesterases, store-operated, store, operated, calcium, SOCE, channels, MDL12330A, Adenylyl Cyclase Inhibitors

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