MDL 12330A hydrochloride
Cat. No. 1436
Chemical Name: (±)-N-[(1R*,2R*)-2-Phenylcyclopentyl
Biological ActivityInhibitor of adenylyl cyclase. Also inhibits cAMP and cGMP phosphodiesterases, and blocks slow extracellular and store-operated Ca2+ entry into cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Guellaen et al (1977) RMI 12330 A, an inhibitor of adenylate cyclase in rat liver. Biochim.Biophys.Acta 484 465. PMID: 911855.
Hunt and Evans (1980) RMI 12330A, an inhibitor of cyclic nucleotide phosphodiesterases and adenylate cyclase in kidney preparations. Biochim.Biophys.Acta 613 499. PMID: 6256001.
van Rossum et al (2000) Ca2+ entry mediated by store depletion, S-nitrosylation, and TRP3 channels. Comparison of coupling and function. J.Biol.Chem. 275 28562. PMID: 10878007.
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Keywords: MDL 12330A hydrochloride, supplier, adenylyl, cyclase, cyclic, AMP, GMP, cAMP, cGMP, PDE, phosphodiesterases, store-operated, store, operated, calcium, SOCE, channels, MDL12330A
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November 15 - 19, 2014
Washington D.C., USA