R&D Systems Inc. Tocris Bioscience Boston Biochem

MDL 12330A hydrochloride

Cat. No. 1436

MDL 12330A hydrochloride C23H36N2.HCl [40297-09-4]

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Chemical Name: (±)-N-[(1R*,2R*)-2-Phenylcyclopentyl]-azacyclotridec-1-en-2-amine hydrochloride

Biological Activity

Inhibitor of adenylyl cyclase. Also inhibits cAMP and cGMP phosphodiesterases, and blocks slow extracellular and store-operated Ca2+ entry into cells.

Technical Data

M.Wt:
377.01
Formula:
C23H36N2.HCl
Solubility:
Soluble to 20 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
40297-09-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Guellaen et al (1977) RMI 12330 A, an inhibitor of adenylate cyclase in rat liver. Biochim.Biophys.Acta 484 465. PMID: 911855.

Hunt and Evans (1980) RMI 12330A, an inhibitor of cyclic nucleotide phosphodiesterases and adenylate cyclase in kidney preparations. Biochim.Biophys.Acta 613 499. PMID: 6256001.

van Rossum et al (2000) Ca2+ entry mediated by store depletion, S-nitrosylation, and TRP3 channels. Comparison of coupling and function. J.Biol.Chem. 275 28562. PMID: 10878007.

If you know of a relevant citation for this product please let us know.

Keywords: MDL 12330A hydrochloride, supplier, adenylyl, cyclase, cyclic, AMP, GMP, cAMP, cGMP, PDE, phosphodiesterases, store-operated, store, operated, calcium, SOCE, channels, MDL12330A

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