Cat. No. 1426
Chemical Name: 4,4',4''-(4-Propyl-[1H]-pyrazole-1,3,5
Biological ActivityPotent, subtype-selective estrogen receptor agonist (EC50 ~ 200 pM); displays 410-fold selectivity for ERα over ERβ. Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Kraichely et al (2000) Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-α and estrogen receptor-β: correlations with biological character and distinct differences among SRC coactivator family members. Endocrinology 141 3534. PMID: 11014206.
Stauffer et al (2000) Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-α-selective agonists. J.Med.Chem. 43 4934. PMID: 11150164.
Harris et al (2002) Characterization of the biological roles of the estrogen receptors, ERα and ERβ, in estrogen target tissues in vivo through the use of an ERα-selective ligand. Endocrinology 143 4172. PMID: 12399409.
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Keywords: PPT, supplier, Subtype-selective, ERα, ERalpha, agonists, ERR, Estrogen, Receptors