PPT

Cat. No. 1426

PPT C24H22N2O3 [263717-53-9]

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Chemical Name: 4,4',4''-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol

Biological Activity

Potent, subtype-selective estrogen receptor agonist (EC50 ~ 200 pM); displays 410-fold selectivity for ERα over ERβ. Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo.

Technical Data

M.Wt:
386.45
Formula:
C24H22N2O3
Solubility:
Soluble to 5 mM in ethanol and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
263717-53-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Kraichely et al (2000) Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-α and estrogen receptor-β: correlations with biological character and distinct differences among SRC coactivator family members. Endocrinology 141 3534. PMID: 11014206.

Stauffer et al (2000) Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-α-selective agonists. J.Med.Chem. 43 4934. PMID: 11150164.

Harris et al (2002) Characterization of the biological roles of the estrogen receptors, ERα and ERβ, in estrogen target tissues in vivo through the use of an ERα-selective ligand. Endocrinology 143 4172. PMID: 12399409.

If you know of a relevant citation for this product please let us know.

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Keywords: PPT, supplier, Subtype-selective, ERα, ERalpha, agonists, ERR, Estrogen, Receptors, Tocris Bioscience, Estrogen and Related Receptor Agonists

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