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Ro 0437626

Cat. No. 2188

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Chemical Name: N-[(1R)-2-[[(1S,2R,3S)-1-(Cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]amino]-2-oxo-1-(4-thiazolylmethyl)ethyl]-1H-benzimidazole-2-carboxamide

Biological Activity

Selective P2X₁ purinergic receptor antagonist (IC₅₀ = 3 μM) that displays > 30-fold selectivity over P2X₂, P2X₃ and P2X_2/3 receptors (IC₅₀ > 100 μM).

Technical Data

M.Wt:

525.66

Formula:

C₂₇H₃₅N₅O₄S

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>98 %

Storage:

Store at -20°C

CAS No:

134362-79-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

King et al (2004) Investigation of the effects of P2 purinoceptor ligands on the micturition reflex in female urethane-anaesthetized rats. Br.J.Pharmacol. 142 519. PMID: 15148261.

Jaime-Figueroa et al (2005) Discovery and synthesis of a novel and selective drug-like P2X₁ antagonist. Bioorg.Med.Chem.Lett. 15 3292. PMID: 15927468.

Ford et al (2006) Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br.J.Pharmacol. 147 S132. PMID: 16465177.

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