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L-AP5

Cat. No. 0107

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Chemical Name: L-(+)-2-Amino-5-phosphonopentanoic acid

Biological Activity

NMDA antagonist. Also agonist at quisqualate-sensitized AP6 site, where it is more potent than the isomer D-AP5 (Cat. No. 0106). Mixture DL-AP5 (Cat. No. 3693) also available.

Technical Data

M.Wt:

197.13

Formula:

C₅H₁₂NO₅P

Solubility:

Soluble to 100 mM in water

Purity:

>99 %

Storage:

Store at RT

CAS No:

79055-67-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Other Information

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service

Safety Data Sheet: View Safety Data Sheet

References

Davies and Watkins (1982) Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 235 378. PMID: 6145492.

Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65. PMID: 7042024.

Schulte et al (1994) Utilization of the resolved L-isomer fo 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 649 203. PMID: 7953634.

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