Cat. No. 0106
Alternative Names: 2-APV, D-APV, D-2-amino-5-phosphonovalerate
Chemical Name: D-(-)-2-Amino-5-phosphonopentanoic acid
Biological ActivityWidely used competitive NMDA antagonist. More active form of AP5. Also agonist at quisqualate-sensitized AP6 site where it is less potent than the L-isomer, L-AP5 (Cat. No. 0107). Also available as part of the Mixed NMDA Receptor Tocriset™ or as a mixed isomer DL-AP5 (Cat. No. 0105).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Davies and Watkins (1982) Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 235 378. PMID: 6145492.
Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65. PMID: 7042024.
Schulte et al (1994) Utilization of the resolved L-isomer fo 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 649 203. PMID: 7953634.
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Keywords: D-AP5, supplier, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGlu, Ionotropic, 2APV, D-APV
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Potent and noncompetitive NMDA receptor antagonist
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