(±)-Anatoxin A fumarate

Cat. No. 0789

()-Anatoxin A fumarate C10H15NO.C4H4O4 [1219922-30-1]

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Chemical Name: (±)-2-Acetyl-9-aza bicyclo[4.2.1]non-2-ene fumarate

Biological Activity

A potent nicotinic agonist (Ki values are 1.25 and 1840 nM for α4β2 and α7 nicotinic receptors respectively). Stimulates [3H]-dopamine release from rat striatal synaptosomes (EC50 = 136 nM).

Technical Data

M.Wt:
281.31
Formula:
C10H15NO.C4H4O4
Solubility:
Soluble to 50 mM in water
Purity:
>96 %
Storage:
Desiccate at +4°C
CAS No:
1219922-30-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Gordon et al (1992) Induced release of acetylcholine from guinea pig ileum longitudinal muscle myenteric plexus by anatoxin-A. J.Pharmacol.Exp.Ther. 263 997. PMID: 1469655.

Stolerman et al (1992) Behavioural effects of anatoxin, a potent nicotinic agonist in rats. Neuropharmacology 31 311. PMID: 1630597.

Thomas et al (1993) (+)-Anatoxin is a potent agonist at neuronal nicotinic acetylcholine receptors. J.Neurochem. 60 2308. PMID: 8492133.

Sharples et al (2000) UB-165 implicates α4β2 nAChR in striatal dopamine release. J.Neurosci. 20 2783. PMID: 10751429.

If you know of a relevant citation for this product please let us know.

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Keywords: ()-Anatoxin A fumarate, supplier, Nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, nAChR, ()-AnatoxinA, fumarate, Tocris Bioscience, Nicotinic Receptor (Non-selective) Agonists

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