R&D Systems Inc. Tocris Bioscience Boston Biochem

(±)-Anatoxin A fumarate

Cat. No. 0789

()-Anatoxin A fumarate C10H15NO.C4H4O4 [122564-82-3]

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Chemical Name: (±)-2-Acetyl-9-aza bicyclo[4.2.1]non-2-ene fumarate

Biological Activity

A potent nicotinic agonist (Ki values are 1.25 and 1840 nM for α4β2 and α7 nicotinic receptors respectively). Stimulates [3H]-dopamine release from rat striatal synaptosomes (EC50 = 136 nM).

Technical Data

M.Wt:
281.31
Formula:
C10H15NO.C4H4O4
Solubility:
Soluble to 50 mM in water
Purity:
>96 %
Storage:
Desiccate at +4°C
CAS No:
122564-82-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Gordon et al (1992) Induced release of acetylcholine from guinea pig ileum longitudinal muscle myenteric plexus by anatoxin-A. J.Pharmacol.Exp.Ther. 263 997. PMID: 1469655.

Stolerman et al (1992) Behavioural effects of anatoxin, a potent nicotinic agonist in rats. Neuropharmacology 31 311. PMID: 1630597.

Thomas et al (1993) (+)-Anatoxin is a potent agonist at neuronal nicotinic acetylcholine receptors. J.Neurochem. 60 2308. PMID: 8492133.

Sharples et al (2000) UB-165 implicates α4β2 nAChR in striatal dopamine release. J.Neurosci. 20 2783. PMID: 10751429.

If you know of a relevant citation for this product please let us know.

Keywords: ()-Anatoxin A fumarate, supplier, Nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, nAChR, ()-AnatoxinA, fumarate

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