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(±)-Anatoxin A fumarateCat. No. 0789 |
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Chemical Name: (±)-2-Acetyl-9-aza bicyclo[4.2.1]non-2-ene fumarate |
Biological Activity
A potent nicotinic agonist (Ki values are 1.25 and 1840 nM for α4β2 and α7 nicotinic receptors respectively). Stimulates [3H]-dopamine release from rat striatal synaptosomes (EC50 = 136 nM).Certificate of Analysis / Safety Data Sheet
References
Gordon et al (1992) Induced release of acetylcholine from guinea pig ileum longitudinal muscle myenteric plexus by anatoxin-A. J.Pharmacol.Exp.Ther. 263 997. PMID: 1469655.
Stolerman et al (1992) Behavioural effects of anatoxin, a potent nicotinic agonist in rats. Neuropharmacology 31 311. PMID: 1630597.
Thomas et al (1993) (+)-Anatoxin is a potent agonist at neuronal nicotinic acetylcholine receptors. J.Neurochem. 60 2308. PMID: 8492133.
Sharples et al (2000) UB-165 implicates α4β2 nAChR in striatal dopamine release. J.Neurosci. 20 2783. PMID: 10751429.
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Keywords: (±)-Anatoxin A fumarate, supplier, Nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, nAChR, (±)-AnatoxinA, fumarate
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