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BVT 948

Cat No. 2176

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Chemical Name: 4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione

Biological Activity

Non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC₅₀ = 0.09 - 1.7 μM); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo. Also inhibits several cytochrome P450 isoforms (IC₅₀ < 10 μM).

Technical Data

M.Wt:

241.25

Formula:

C₁₄H₁₁NO₃

Solubility:

Soluble to 50 mM in ethanol and to 50 mM in DMSO

Purity:

>98 %

Storage:

Store at RT

CAS No:

[39674-97-0]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

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References

Liljebris et al (2004) Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione. J.Pharmacol.Exp.Ther. 309 711.

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Phosphatases

Protein Tyrosine Phosphatases

Keywords: BVT 948, Non-competitive, protein, tyrosine, phosphatase, inhibitors, enhances, insulin, signaling, PTP, Shp1, Shp2, Protein, Tyrosine, Phosphatases, BVT948