R&D Systems Inc. Tocris Bioscience Boston Biochem

2-Cl-IB-MECA

Cat. No. 1104

2-Cl-IB-MECA C18H18ClIN6O4 [163042-96-4]

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Chemical Name: 1-[2-Chloro-6-[[(3-iodophenyl)methy­l]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-β-D-ribofu­ranuronamide

Biological Activity

High affinity and extremely selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively. Exhibits high selectivity over the Na+-independent adenosine transporter.

Licensing Information

Sold with the permission of the NIH, US Patent 08/091,109

Technical Data

M.Wt:
544.74
Formula:
C18H18ClIN6O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
163042-96-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Kim et al (1994) 2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors. J.Med.Chem. 37 3614. PMID: 7932588.

Schaick et al (1996) Hemodynamic effects of histamine release elicited by the selective adenosine A3 receptor agonist 2-Cl-IB-MECA in conscious rats. Eur.J.Pharmacol. 308 311. PMID: 8858305.

Jacobson (1998) Adenosine A3 receptors: novel ligands and paradoxical effects. TiPS 19 184. PMID: 9652191.

If you know of a relevant citation for this product please let us know.

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