Cat. No. 0940
Alternative Name: 4-AP
Biological ActivityNon-selective voltage-dependent K+-channel blocker (IC50 values are 170 and 230 μM at KV1.1 and KV1.2 respectively). Caged 4-AP (Cat. No. 3557) is also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Bouchard and Fedida (1995) Closed and open state binding of 4-aminopyridine to the cloned human potassium channel Kv1.5. J.Pharmacol.Exp.Ther. 275 864. PMID: 7473178.
Tseng et al (1996) Reverse use dependence of Kv4.2 blockade by 4-aminopyridine. J.Pharmacol.Exp.Ther. 279 865. PMID: 8930194.
Tseng (1999) Different state dependencies of 4-aminopyridine binding to rKv1.4 and rKv4.2: role of the cytoplasmic halves of the fifth and sixth transmembrane segments. J.Pharmacol.Exp.Ther. 290 569. PMID: 10411564.
Smith et al (2009) In vitro electrophysiological activity of nerispirdine, a novel 4-aminopyridine derivative. Clin.Exp.Pharmacol.Physiol. 36 1104. PMID: 19413590.
If you know of a relevant citation for this product please let us know.
Keywords: 4-Aminopyridine, supplier, K+, channel, blocker, Potassium, Channels, voltage-gated, voltage-dependent, Kv, hERG, Human, Ether-A-Go-Go, Gene, KCNQ
Find multiple products by catalog number
New Products in this Area
KV4 channel blockerSpadin
Potent TREK-1 channel inhibitorLei-Dab 7
High affinity, selective KCa2.2 blockerNS 8593 hydrochloride
Selective KCa2 (SK) channel negative modulator; inhibits SK currentsPK-THPP
Potent TASK-3 channel blocker
December 15 - 17, 2015