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4-Aminopyridine

Cat. No. 0940

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Alternative Name: 4-AP

Biological Activity

Non-selective voltage-dependent K⁺-channel blocker (IC₅₀ values are 170 and 230 μM at K_V1.1 and K_V1.2 respectively). Caged 4-AP (Cat. No. 3557) is also available.

Technical Data

M.Wt:

94.12

Formula:

C₅H₆N₂

Solubility:

Soluble to 100 mM in water

Purity:

>99 %

Storage:

Store at RT

CAS No:

504-24-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Bouchard and Fedida (1995) Closed and open state binding of 4-aminopyridine to the cloned human potassium channel Kv1.5. J.Pharmacol.Exp.Ther. 275 864. PMID: 7473178.

Tseng et al (1996) Reverse use dependence of Kv4.2 blockade by 4-aminopyridine. J.Pharmacol.Exp.Ther. 279 865. PMID: 8930194.

Tseng (1999) Different state dependencies of 4-aminopyridine binding to rKv1.4 and rKv4.2: role of the cytoplasmic halves of the fifth and sixth transmembrane segments. J.Pharmacol.Exp.Ther. 290 569. PMID: 10411564.

Smith et al (2009) In vitro electrophysiological activity of nerispirdine, a novel 4-aminopyridine derivative. Clin.Exp.Pharmacol.Physiol. 36 1104. PMID: 19413590.

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Keywords: 4-Aminopyridine, supplier, K+, channel, blocker, Potassium, Channels, voltage-gated, voltage-dependent, Kv, hERG, Human, Ether-A-Go-Go, Gene, KCNQ