R&D Systems Inc. Tocris Bioscience Boston Biochem

Bax channel blocker

Cat. No. 2160

Bax channel blocker C19H21Br2N3O.2HCl [329349-20-4]

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Chemical Name: 3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride

Biological Activity

Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 μM). Suggested to inhibit Bax channel formation/activity.

Technical Data

M.Wt:
540.12
Formula:
C19H21Br2N3O.2HCl
Solubility:
Soluble to 5 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
329349-20-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Bombrun et al (2003) 3,6-Dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. J.Med.Chem. 46 21.

If you know of a relevant citation for this product please let us know.

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Keywords: Bax channel blocker, supplier, inhibitors, Bax-mediated, mitochondrial, cytochrome, c, release, Bcl-2, Family

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