Cat. No. 2154
Chemical Name: 4-[2-[[(2R)-2-Hydroxy-2-phenylethyl]amino]ethoxy]-benzeneacetic acid hydrochloride
Biological Activityβ3-adrenoceptor agonist. Relaxes rat mesenteric artery and isolated aorta in vitro. Inhibits ob gene expression and circulating leptin levels in lean mice in vivo.
Licensing InformationSold with the permission of AstraZeneca UK Ltd.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Trayhurn et al (1996) Rapid inhibition of ob gene expression and circulating leptin levels in lean mice by the β3-adrenoceptor agonists BRL 35135A and ZD2079. Biochem.Biophys.Res.Comm. 228 605.
Brawley et al (2000) Role of endothelium/nitric oxide in atypical β-adrenoceptor-mediated relaxation in rat isolated aorta. Eur.J.Pharmacol. 398 285. PMID: 10854841.
Kozlowska et al (2003) Atypical β-adrenoceptors, different from β3-adrenoceptors, relax the rat isolated mesenteric artery. Br.J.Pharmacol. 140 3. PMID: 12967929.
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Keywords: ZD 2079, supplier, β3-adrenoceptor, b3-adrenoceptor, β3-adrenergic, b3-adrenergic, agonists, Receptors, ZD2079, AstraZeneca
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