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Melittin

Cat. No. 1193

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Biological Activity

Inhibits G_s and stimulates G_i activity. Inhibits protein kinase C and cAMP-dependent protein kinases. Na⁺/K⁺ ATPase inhibitor.

Technical Data

M.Wt:

2847

Formula:

C₁₃₁H₂₂₉N₃₉O₃₁

Sequence:

GIGAVLKVLTTGLPALISWIKRKRQQ

(Modifications: Gln-26 = C-terminal amide)

Solubility:

Soluble to 1 mg/ml in 20% acetonitrile

Storage:

Desiccate at -20°C

CAS No:

20449-79-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Mousli et al (1990) G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides. TiPS 11 358. PMID: 2122563.

Raynor et al (1991) Membrane interactions of amphiphilic polypeptides mastoparan, melittin, plymixin B and cardiotoxin. J.Biol.Chem. 266 2753. PMID: 1847132.

Fukushima et al (1998) Melittin, a metabostatic peptide inhibiting G_s activity. Peptides 5 811. PMID: 9663445.

If you know of a relevant citation for this product please let us know.

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