MDL 28170Cat No. 1146 |
Price and Availability |
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Chemical Name: N-[N-[(Phenylmethoxy)carbonyl]-L-valyl]-phenylalaninal |
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Biological Activity
Potent, selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Mehdi (1991) Cell-penetrating inhibitor of calpain. TiBS 16 150. Chen et al (1997) Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL 28170. Brain Res. 769 188. Li et al (1998) Postischemic treatment with a calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia. Neurosci.Lett. 247 17.If you know of a useful citation for this product please let us know.
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Keywords: MDL 28170, Potent, selective, calpain, cathepsin, B, inhibitor, Proteinases, Proteases, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling, MDL28170
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