Home » Cellular Processes » Apoptosis » 14.3.3 Proteins » Difopein

Difopein

Cat. No. 2145

Price and Availability

For Difopein pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Biological Activity

Dimeric version of R18 peptide (Cat. No. 2144) that binds to 14.3.3 proteins with high affinity. Competitively inhibits 14.3.3-ligand interactions; blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S. Induces apoptosis when expressed in COS-7 and various cancer cells.

Technical Data

M.Wt:

6387.17

Formula:

C₂₇₃H₄₂₄N₇₆O₈₉S₆

Sequence:

SADGAPHCVPRDLSWLDLEANMCLPGAAGLDSADGAPHCVPRDLSWLDLEANMCLPGAAGLE

Solubility:

Soluble to 5 mg/ml in water

Storage:

Desiccate at -20°C

CAS No:

396834-58-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Select another batch:

Safety Data Sheet: View Safety Data Sheet

References

Masters and Fu (2001) 14.3.3 proteins mediate an essential anti-apoptotic signal. J.Biol.Chem. 276 45193. PMID: 11577088.

Masters et al (2002) Survival-promoting functions of 14.3.3 proteins. Biochem.Soc.Transactions 30 360.

Hermeking (2003) The 14.3.3 cancer connection. Nature Rev.Cancer 3 931.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

14.3.3 Proteins Apoptosis

Epigenetics

Keywords: Difopein, supplier, High, affinity, inhibitors, 1433, proteins, induces, apoptosis, 14-3-3, 14.3.3

Quick Order

Find multiple products by catalog number

Cancer Research Guide

Request your free copy

Highlights over 350 products for cancer research. Request a copy or view PDF today.

Checkpoint Kinases & the DNA Damage Response

Written by Michelle D. Garrett and Ian Collins

A summary of the response of the checkpoint kinase signaling network to DNA damage, including activation of DNA repair, cell-cycle arrest, senescence and apoptosis.

Programmed Cell Death

Written by Bram van Raam and Guy Salvesen

A summary of the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation. Request a copy or view PDF today.