Cat. No. 2145
Biological ActivityDimeric version of R18 peptide (Cat. No. 2144) that binds to 14.3.3 proteins with high affinity. Competitively inhibits 14.3.3-ligand interactions; blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S. Induces apoptosis when expressed in COS-7 and various cancer cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Masters and Fu (2001) 14.3.3 proteins mediate an essential anti-apoptotic signal. J.Biol.Chem. 276 45193. PMID: 11577088.
Masters et al (2002) Survival-promoting functions of 14.3.3 proteins. Biochem.Soc.Transactions 30 360.
Hermeking (2003) The 14.3.3 cancer connection. Nature Rev.Cancer 3 931.
If you know of a relevant citation for this product please let us know.
Keywords: Difopein, supplier, High, affinity, inhibitors, 1433, proteins, induces, apoptosis, 14-3-3, 14.3.3
Find multiple products by catalog number
New Products in this Area
High affinity and selective activator of BaxCladribine
Deoxyadenosine analog; pro-apoptoticUC 112
IAP and XIAP inhibitor; antitumorAZD 5582 dihydrochloride
Dimeric Smac mimetic; potent IAP inhibitor
December 16 - 18, 2014
Booth Number: 12