Cat. No. 2145
Biological ActivityDimeric version of R18 peptide (Cat. No. 2144) that binds to 14.3.3 proteins with high affinity. Competitively inhibits 14.3.3-ligand interactions; blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S. Induces apoptosis when expressed in COS-7 and various cancer cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Masters and Fu (2001) 14.3.3 proteins mediate an essential anti-apoptotic signal. J.Biol.Chem. 276 45193. PMID: 11577088.
Masters et al (2002) Survival-promoting functions of 14.3.3 proteins. Biochem.Soc.Transactions 30 360.
Hermeking (2003) The 14.3.3 cancer connection. Nature Rev.Cancer 3 931.
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Keywords: Difopein, supplier, High, affinity, inhibitors, 1433, proteins, induces, apoptosis, 14-3-3, 14.3.3
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December 16, 2013