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Daunorubicin hydrochlorideCat. No. 1467 |
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Alternative Name: Daunomycin Chemical Name: (8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyransoyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride |
Biological Activity
Anticancer agent that is clinically used to treat nonlymphocytic leukemia. Inhibits RNA and DNA synthesis and causes DNA fragmentation in vivo.Certificate of Analysis / Safety Data Sheet
References
Aubel-Sadron and Londos-Gagliardi (1984) Daunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological review. Biochimie 66 333. PMID: 6380596.
Gewirtz (1999) A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem.Pharmacol. 57 727. PMID: 10075079.
Laurent and Jaffrezou (2001) Signaling pathways activated by daunorubicin. Blood 98 913. PMID: 11493433.
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Keywords: Daunorubicin hydrochloride, supplier, RNA, synthesis, inhibitors, antibiotics
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