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DexamethasoneCat. No. 1126 |
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Chemical Name: (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione |
Biological Activity
Glucocorticoid; anti-inflammatory. Reduces levels of activated NF-κB in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. Induces differentiation of human mesenchymal stem cells (MSCs). Also induces autophagy in acute lymphoblastic leukemia (ALL) cell lines.Certificate of Analysis / Safety Data Sheet
References
Merck Index 12 2986.
Teixeira et al (1996) Effects of dexamethasone and cyclosporin A on the accumulation of eosinophils in acute cutaneous inflammation in the guinea-pig. Br.J.Pharmacol. 118 317. PMID: 8735633.
Matasic et al (1999) Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells. J.Leukoc.Biol. 66 909. PMID: 10614771.
Laane et al (2009) Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy. Cell Death Differ. 16 1018. PMID: 19390558.
Sittichokechaiwut et al (2010) Short bouts of mechanical loading are as effective as dexamethasone at inducing matrix production by human bone marrow mesenchymal stem cell. Eur.Cell Mater. 20 45. PMID: 20648425.
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Keywords: Dexamethasone, supplier, Anti-inflammatory, glucocorticoid, receptor, Receptors, induces, differentiation
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