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AACOCF3Cat. No. 1462 |
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Alternative Name: Arachidonyl trifluoromethyl ketone Chemical Name: 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosateraen-2-one |
Biological Activity
Inhibitor of cytosolic (85 kDa) phospholipase A2. Also inhibits fatty acid amide hydrolase (FAAH, anandamide amidase) in vitro.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
References
Koutek et al (1994) Inhibitors of arachidonoyl ethanolamide hydrolysis. J.Biol.Chem. 269 22937. PMID: 8083191.
Riendeau et al (1994) Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. J.Biol.Chem. 269 15619. PMID: 8195210.
Rastogi and McHowat (2009) Inhibition of calcium-independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium. Respir.Physiol.Neurobiol. 165 167. PMID: 19059366.
If you know of a relevant citation for this product please let us know.
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Keywords: AACOCF3, supplier, FAAH, inhibitors, Phospholipases, A2, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, PLA2, Esterases, Cannabinoids, Receptors
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