Cat. No. 1462

AACOCF3 C21H31F3O [149301-79-1]

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Alternative Name: Arachidonyl trifluoromethyl ketone

Chemical Name: 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosateraen-2-one

Biological Activity

Inhibitor of cytosolic (85 kDa) phospholipase A2. Also inhibits fatty acid amide hydrolase (FAAH, anandamide amidase) in vitro.

Technical Data

Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Koutek et al (1994) Inhibitors of arachidonoyl ethanolamide hydrolysis. J.Biol.Chem. 269 22937. PMID: 8083191.

Riendeau et al (1994) Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. J.Biol.Chem. 269 15619. PMID: 8195210.

Rastogi and McHowat (2009) Inhibition of calcium-independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium. Respir.Physiol.Neurobiol. 165 167. PMID: 19059366.

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View Related Products by Product Action

Keywords: AACOCF3, supplier, FAAH, inhibitors, Phospholipases, A2, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, PLA2, Esterases, Cannabinoids, Receptors, Phospholipase Inhibitors

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