R&D Systems Inc. Tocris Bioscience Boston Biochem

AACOCF3

Cat. No. 1462

AACOCF3 C21H31F3O [149301-79-1]

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Alternative Name: Arachidonyl trifluoromethyl ketone

Chemical Name: 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosateraen-2-one

Biological Activity

Inhibitor of cytosolic (85 kDa) phospholipase A2. Also inhibits fatty acid amide hydrolase (FAAH, anandamide amidase) in vitro.

Technical Data

M.Wt:
356.47
Formula:
C21H31F3O
Solubility:
Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)
Storage:
Desiccate at -20°C
CAS No:
149301-79-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Koutek et al (1994) Inhibitors of arachidonoyl ethanolamide hydrolysis. J.Biol.Chem. 269 22937. PMID: 8083191.

Riendeau et al (1994) Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. J.Biol.Chem. 269 15619. PMID: 8195210.

Rastogi and McHowat (2009) Inhibition of calcium-independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium. Respir.Physiol.Neurobiol. 165 167. PMID: 19059366.

If you know of a relevant citation for this product please let us know.

Keywords: AACOCF3, supplier, FAAH, inhibitors, Phospholipases, A2, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, PLA2, Esterases, Cannabinoids, Receptors

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