Amiloride hydrochloride

Cat No. 0890

Amiloride hydrochloride
 C6H8CIN7O.HCl [2016-88-8]

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Chemical Name: 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarbox amide hydrochloride

Biological Activity

Na+ channel blocker. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding sites. Also inhibits TRPP3 channels.

Technical Data

M.Wt:
266.09
Formula:
C6H8CIN7O.HCl
Solubility:
Soluble to 10 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
[2016-88-8]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Certificate of Analysis / MSDS

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Material Safety Data Sheet: View current batch
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References

Merck Index 12 426. Kleyman et al (1988) Amiloride and its analogues as tools in the study of ion transport. J.Membr.Biol. 105 1. Ernsberger et al (1992) A second generation of centrally acting antihypertensive agents act on putative I1-imidazoline receptors. J.Cardiovasc.Pharmacol. 20 S1. Hamill and McBride (1996) The pharmacology of mechanogated membrane ion channels. Pharmacol.Rev. 48 231. Dai et al (2007) Inhibition of TRPP3 channel by amiloride and analogs. J.Pharmacol.Exp.Ther. 72 1576.

If you know of a useful citation for this product please let us know.

Keywords: Amiloride hydrochloride, I2, selective, ligands, differentiates, I2A, I2B, Na+, channel, blockers, Imidazoline, Receptors, Sodium, NaV, Channels, voltage-gated, voltage-dependent

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