Amiloride hydrochloride

Cat No. 0890

Amiloride hydrochloride
 C6H8CIN7O.HCl [2016-88-8]

Price and Availability

For Amiloride hydrochloride pricing & availability please select your country from the drop down menu:
Submit

Chemical Name: 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarbox amide hydrochloride

Biological Activity

Na+ channel blocker. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding sites. Also inhibits TRPP3 channels.

Technical Data

M.Wt:
266.09
Formula:
C6H8CIN7O.HCl
Solubility:
Soluble to 10 mM in Water
Purity:
>99 %
Storage:
Store at RT
CAS No:
[2016-88-8]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch
For specific/earlier batch please select:  
Material Safety Data Sheet: View current batch
For specific/earlier batch please select:  

References

Merck Index 12 426. Kleyman et al (1988) Amiloride and its analogues as tools in the study of ion transport. J.Membr.Biol. 105 1. Ernsberger et al (1992) A second generation of centrally acting antihypertensive agents act on putative I1-imidazoline receptors. J.Cardiovasc.Pharmacol. 20 S1. Hamill and McBride (1996) The pharmacology of mechanogated membrane ion channels. Pharmacol.Rev. 48 231. Dai et al (2007) Inhibition of TRPP3 channel by amiloride and analogs. J.Pharmacol.Exp.Ther. 72 1576.

Keywords: Amiloride hydrochloride, I2, selective, ligands, differentiates, I2A, I2B, Na+, channel, blockers, Imidazoline, Receptors, Sodium, NaV, Channels, voltage-gated, voltage-dependent,

Buy Now / Print Quote

Find multiple products by catalog number


divider line

Signal Transduction Guide

Signal Transduction Guide

A collection of more than 600 products for signal transduction research. View PDF today.

request
divider line

Cancer Research Guide

Cancer Research Guide

Highlights over 400 products for cancer research. Request a copy or view PDF today.

request
divider line

Calcium Imbalance and Neuroprotective Targets

Written by E. Besancon et al

Neuroprotection Poster

'Calcium Imbalance and Neuro-protective Targets in Cerebral Ischemia & Brain Injury' highlights the key targets involved in stroke, trauma and neurodegeneration.

request
divider line

RSS News Feed

Find out about new products as soon as they go live!

Get the Tocris RSS feed

Click on the orange RSS button to read more about our RSS feed and actively opt in.

more