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Amiloride hydrochloride

Cat No. 0890

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Chemical Name: 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarbox amide hydrochloride

Biological Activity

Na⁺ channel blocker. Defines the I_2A-amiloride sensitive and I_2B-amiloride insensitive imidazoline binding sites. Also inhibits TRPP3 channels.

Technical Data

M.Wt:

266.09

Formula:

C₆H₈CIN₇O.HCl

Solubility:

Soluble to 10 mM in water

Purity:

>99 %

Storage:

Store at RT

CAS No:

[2016-88-8]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

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Material Safety Data Sheet: View current batch

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References

Merck Index 12 426. Kleyman et al (1988) Amiloride and its analogues as tools in the study of ion transport. J.Membr.Biol. 105 1. Ernsberger et al (1992) A second generation of centrally acting antihypertensive agents act on putative I₁-imidazoline receptors. J.Cardiovasc.Pharmacol. 20 S1. Hamill and McBride (1996) The pharmacology of mechanogated membrane ion channels. Pharmacol.Rev. 48 231. Dai et al (2007) Inhibition of TRPP3 channel by amiloride and analogs. J.Pharmacol.Exp.Ther. 72 1576.

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Sodium Channels Voltage-gated Sodium (Na_V) Channels

Keywords: Amiloride hydrochloride, I2, selective, ligands, differentiates, I2A, I2B, Na+, channel, blockers, Imidazoline, Receptors, Sodium, NaV, Channels, voltage-gated, voltage-dependent

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