Amiloride hydrochloride
Cat No. 0890
Price and Availability
Chemical Name: 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarbox amide hydrochloride
Biological Activity
Na+ channel blocker. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding sites. Also inhibits TRPP3 channels.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Merck Index 12 426. Kleyman et al (1988) Amiloride and its analogues as tools in the study of ion transport. J.Membr.Biol. 105 1. Ernsberger et al (1992) A second generation of centrally acting antihypertensive agents act on putative I1-imidazoline receptors. J.Cardiovasc.Pharmacol. 20 S1. Hamill and McBride (1996) The pharmacology of mechanogated membrane ion channels. Pharmacol.Rev. 48 231. Dai et al (2007) Inhibition of TRPP3 channel by amiloride and analogs. J.Pharmacol.Exp.Ther. 72 1576.View Related Products by Target
Keywords: Amiloride hydrochloride, I2, selective, ligands, differentiates, I2A, I2B, Na+, channel, blockers, Imidazoline, Receptors, Sodium, NaV, Channels, voltage-gated, voltage-dependent,
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