PNU 37883 hydrochloride
Cat. No. 2095
Chemical Name: N-Cyclohexyl-N'-tricyclo[184.108.40.206,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride
Biological ActivityNovel antagonist selective for the vascular form of Kir6 (KATP) channel; inhibits Kir6 currents in isolated mesenteric artery smooth muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes. Inhibits blood vessel relaxation and hypotension induced by pinacidil in vivo. Displays weak diuretic effects.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Humphrey and Ludens (1998) KATP-blocking diuretic PNU-37883A reduces plasma renin activity in dogs. J.Cardiovasc.Pharmacol. 31 894. PMID: 9641474.
Cui et al (2003) Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A. Br.J.Pharmacol. 139 122. PMID: 12746230.
Kovalev et al (2004) Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883A. Br.J.Pharmacol. 141 867. PMID: 14757705.
If you know of a relevant citation for this product please let us know.
Keywords: PNU 37883 hydrochloride, supplier, Vascular, KATP, channels, blockers, Potassium, KIR, Inward, Rectifier, K+, PNU37883, hydrochloride, antagonist, Kir6
Find multiple products by catalog number
New Products in this Area
Potent KCa3.1 channel blockerADWX 1
Potent and selective KV1.3 channel blockerCesium chloride
Potassium channel blocker; neuroprotective
Win a Kindle
May 21 - 24, 2013
Booth Number: 32