R&D Systems Inc. Tocris Bioscience Boston Biochem

PNU 37883 hydrochloride

Cat. No. 2095

PNU 37883 hydrochloride C21H35N3O.HCl [57568-80-6]

Price and Availability

For PNU 37883 hydrochloride pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-Cyclohexyl-N'-tricyclo[,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride

Biological Activity

Novel antagonist selective for the vascular form of Kir6 (KATP) channel; inhibits Kir6 currents in isolated mesenteric artery smooth muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes. Inhibits blood vessel relaxation and hypotension induced by pinacidil in vivo. Displays weak diuretic effects.

Technical Data

Soluble to 25 mM in DMSO and to 100 mM in ethanol
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Humphrey and Ludens (1998) KATP-blocking diuretic PNU-37883A reduces plasma renin activity in dogs. J.Cardiovasc.Pharmacol. 31 894. PMID: 9641474.

Cui et al (2003) Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A. Br.J.Pharmacol. 139 122. PMID: 12746230.

Kovalev et al (2004) Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883A. Br.J.Pharmacol. 141 867. PMID: 14757705.

If you know of a relevant citation for this product please let us know.

Keywords: PNU 37883 hydrochloride, supplier, Vascular, KATP, channels, blockers, Potassium, KIR, Inward, Rectifier, K+, PNU37883, hydrochloride, antagonist, Kir6

Quick Order

Find multiple products by catalog number

divider line

New Product E-alerts

Sign up for email updates from Tocris


Enter your email address below to sign up to receive our email updates:

divider line

New Products in this Area

ML 297

Selective Kir3.1/3.2 (GIRK1/2) channel activator

ML 365

Potent and selective TASK-1 channel blocker

HMR 1556

Potent and selective Iks channel blocker

NS 19504

Activator of BKCa (KCa1.1) channels

Sign-up for new product e-alerts
divider line

Bio-Techne Events

12th Congress of the French Neuroscience Society

12th Congress of the French Neuroscience Society

May 19 - 22, 2015

Montpelier, France