Home » Pharmacology » Ion Channels » Potassium Channels » Inward Rectifier Potassium (K_ir) Channels » PNU 37883 hydrochloride

PNU 37883 hydrochloride

Cat. No. 2095

Price and Availability

For PNU 37883 hydrochloride pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-Cyclohexyl-N'-tricyclo[3.3.1.13,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride

Biological Activity

Novel antagonist selective for the vascular form of K_ir6 (K_ATP) channel; inhibits K_ir6 currents in isolated mesenteric artery smooth muscle cells (K_d = 65 nM) but not in cardiac or skeletal myocytes. Inhibits blood vessel relaxation and hypotension induced by pinacidil in vivo. Displays weak diuretic effects.

Technical Data

M.Wt:

381.98

Formula:

C₂₁H₃₅N₃O.HCl

Solubility:

Soluble to 25 mM in DMSO and to 100 mM in ethanol

Purity:

>99 %

Storage:

Desiccate at RT

CAS No:

57568-80-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Humphrey and Ludens (1998) K_ATP-blocking diuretic PNU-37883A reduces plasma renin activity in dogs. J.Cardiovasc.Pharmacol. 31 894. PMID: 9641474.

Cui et al (2003) Different molecular sites of action for the K_ATP channel inhibitors, PNU-99963 and PNU-37883A. Br.J.Pharmacol. 139 122. PMID: 12746230.

Kovalev et al (2004) Molecular analysis of the subtype-selective inhibition of cloned K_ATP channels by PNU-37883A. Br.J.Pharmacol. 141 867. PMID: 14757705.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Inward Rectifier Potassium (K_ir) Channels

Potassium Channels

Keywords: PNU 37883 hydrochloride, supplier, Vascular, KATP, channels, blockers, Potassium, KIR, Inward, Rectifier, K+, PNU37883, hydrochloride, antagonist, Kir6