Methyllycaconitine citrate

Cat No. 1029

Methyllycaconitine citrate C37H50N2O10.C6H8O7 [21019-30-7]

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Alternative Name: MLA

Chemical Name: [1a,4(S),6b,14a,16b]-20-Ethyl-1,6,14,16-tetramethoxy-4- [[[2-(3-methyl-2,5- dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-d iol citrate

Biological Activity

Potent antagonist for α7-containing neuronal nicotinic receptors (Ki = 1.4 nM). Interacts with α4β2 and α6β2 receptors at concentrations > 40 nM. Attenuates METH-induced neurotoxicity in mouse striatum in vivo.

Technical Data

M.Wt:
874.93
Formula:
C37H50N2O10.C6H8O7
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Desiccate at -20°C
CAS No:
[21019-30-7]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch
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Material Safety Data Sheet: View current batch
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References

Ward et al (1990) Methyllycaconitine: a selective probe for neuronal a-bungarotoxin binding sites. FEBS Lett. 270 45. Dobelis et al (1999) Effects of delphinium alkaloids on neuromuscular transmission. J.Pharmacol.Exp.Ther. 291 538. Escubedo et al (2005) Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum: involvement of a7 nicotinic receptors. J.Pharmacol.Exp.Ther. 315 658.

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