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Ambenonium dichloride

Cat. No. 0388

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Chemical Name: N,N'-[(1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis(2-chloro-N,N-diethylbenzenemethaminium) dichloride

Biological Activity

Extremely potent, selective and rapidly reversible inhibitor of acetylcholinesterase (AChE) (IC₅₀ values are 0.000698 and 8.20 μM at AChE and BChE respectively).

Technical Data

M.Wt:

608.48

Formula:

C₂₈H₄₂Cl₄N₄O₂

Solubility:

Soluble to 100 mM in water

Purity:

>99 %

Storage:

Store at RT

CAS No:

52022-31-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Lands et al (1958) An investigation of the structure-activity correlations within a series of ambenonium analogs. J.Pharmacol.Exp.Ther. 123 121. PMID: 13550066.

Web (1965) Affinity for benzoquinonium, and ambenonium derivatives for the acetylcholine receptor, tested on the electroplax, and for acetylcholinesterase in solution. Biochim.Biophys.Acta. 102 172. PMID: 5833399.

Hodge et al (1992) Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities. Mol.Pharmacol. 41 937. PMID: 1588924.

Bolognesi et al (2003) Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors. Farmaco 58 917. PMID: 13679187.

If you know of a relevant citation for this product please let us know.

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