Ambenonium dichloride

Cat. No. 0388

Ambenonium dichloride C28H42Cl4N4O2 [115-79-7]

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Chemical Name: N,N'-[(1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis(2-chloro-N,N-diethylbenzenemethaminium) dichloride

Biological Activity

Extremely potent, selective and rapidly reversible inhibitor of acetylcholinesterase (AChE) (IC50 values are 0.000698 and 8.20 μM at AChE and BChE respectively).

Technical Data

M.Wt:
608.48
Formula:
C28H42Cl4N4O2
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
115-79-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Lands et al (1958) An investigation of the structure-activity correlations within a series of ambenonium analogs. J.Pharmacol.Exp.Ther. 123 121. PMID: 13550066.

Web (1965) Affinity for benzoquinonium, and ambenonium derivatives for the acetylcholine receptor, tested on the electroplax, and for acetylcholinesterase in solution. Biochim.Biophys.Acta. 102 172. PMID: 5833399.

Hodge et al (1992) Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities. Mol.Pharmacol. 41 937. PMID: 1588924.

Bolognesi et al (2003) Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors. Farmaco 58 917. PMID: 13679187.

If you know of a relevant citation for this product please let us know.

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Keywords: Ambenonium dichloride, supplier, Cholinesterase, inhibitors, AChE, Acetylcholinesterase, Esterases, Acetylcholine, Tocris Bioscience, Cholinesterase Inhibitors

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