Cat. No. 0388
Chemical Name: N,N'-[(1,2-Dioxo-1,2-ethanediyl)bis(
Biological ActivityExtremely potent, selective and rapidly reversible inhibitor of acetylcholinesterase (AChE) (IC50 values are 0.000698 and 8.20 μM at AChE and BChE respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Lands et al (1958) An investigation of the structure-activity correlations within a series of ambenonium analogs. J.Pharmacol.Exp.Ther. 123 121. PMID: 13550066.
Web (1965) Affinity for benzoquinonium, and ambenonium derivatives for the acetylcholine receptor, tested on the electroplax, and for acetylcholinesterase in solution. Biochim.Biophys.Acta. 102 172. PMID: 5833399.
Hodge et al (1992) Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities. Mol.Pharmacol. 41 937. PMID: 1588924.
Bolognesi et al (2003) Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors. Farmaco 58 917. PMID: 13679187.
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Keywords: Ambenonium dichloride, supplier, Cholinesterase, inhibitors, AChE, Acetylcholinesterase, Esterases, Acetylcholine
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December 6 - 10, 2014
Booth Number: 515