R&D Systems Inc. Tocris Bioscience Boston Biochem

SU 4312

Cat. No. 1459

SU 4312 C17H16N2O [5812-07-7]

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Alternative Name: DMBI

Chemical Name: 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one

Biological Activity

Potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). Selective over EGFR and c-Src tyrosine kinases.

Technical Data

M.Wt:
264.33
Formula:
C17H16N2O
Solubility:
Soluble to 100 mM in DMSO
Storage:
Desiccate at -20°C
CAS No:
5812-07-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Sun et al (1998) Synthesis and biological evaluations of 3-substituted indol-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J.Med.Chem. 41 2588. PMID: 9651163.

Zaman et al (1998) Tyrosine kinase activity of purified recombinant cytoplasmic domain of platelet-derived growth factor β-receptor (β-PDGFR) and discovery of a novel inhibitor of receptor tyrosine kinases. Biochem.Pharmacol. 57 57. PMID: 9920285.

Kendall et al (1999) Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues. J.Biol.Chem. 274 6453. PMID: 10037737.

If you know of a relevant citation for this product please let us know.

Keywords: SU 4312, supplier, Potent, inhibitors, VEGFR, tyrosine, kinase, Vascular, Endothelial, Growth, Factor, Receptors, KDR, Flt, Receptor, Tyrosine, Kinases, RTKs, SU4312

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