RS 102895 hydrochloride
Cat. No. 2089
Chemical Name: 1'-[2-[4-(Trifluoromethyl)phenyl]eth
Biological ActivityCCR2-selective chemokine receptor antagonist (IC50 values are 0.36 and 17.8 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC50 values of 32 nM and 1.7 μM respectively. Also inhibits α1A, α1D and 5-HT1A receptors.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Clark et al (1983) Synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'piperidin]-2(1H)-ones. J.Med.Chem. 26 657. PMID: 6842505.
Mirzadegan et al (2000) Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists. J.Biol.Chem. 275 25562. PMID: 10770925.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: RS 102895 hydrochloride, supplier, CCR2b, chemokine, receptor, antagonists, Chemokine, Receptors, RS102895, hydrochloride
Find multiple products by catalog number
New Products in this Area
Selective FFA1 (GPR40) agonist(±)-NBI 74330
Potent and selective CXCR3 antagonistPurmorphamine
Smo receptor agonistCTCE 9908
CXCR4 antagonist; antitumorVUF 11207 fumarate
Potent CXCR7 agonistTC-G 1006
Potent and selective sphingosine-1-phosphate receptor 1 (S1P1) agonistDMNPE-caged ATP diammonium salt
Caged ATPMK 1903
Potent and selective GPR109A (HCA2) agonistM 25
Potent Smoothened (Smo) receptor antagonistKi 16425
LPA1 and LPA3 receptor antagonistCYM 50358 hydrochloride
Potent and selective S1P4 antagonist(±)-AMG 487
CXCR3 antagonist; inhibits cell migration and metastasisGW 627368
Selective EP4 receptor competitive antagonist
Meet your representative
July 15, 2014