RS 39604 hydrochloride
Cat. No. 0991
Chemical Name: 1-[4-Amino-5-chloro-2-(3,5-dimethox
Biological ActivityA potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and α1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies.
Licensing InformationSold with the permission of Roche Bioscience
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Eglen et al (1995) Central 5-HT4 receptors TiPS 16 391. PMID: 8578609.
Hegde (1995) RS 39604: a potent, selective and orally active 5-HT4 receptor antagonist. Br.J.Pharmacol. 115 1087. PMID: 7582507.
If you know of a relevant citation for this product please let us know.
View Related Products by Product Action
Keywords: RS 39604 hydrochloride, supplier, 5-HT4, antagonist, Serotonin, Receptors, 5-Hydroxytryptamine, RS39604, hydrochloride, Tocris Bioscience, 5-HT4 Receptor Antagonists
Find multiple products by catalog number
New Products in this Area
High affinity and selective 5-HT6 agonist
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.