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RS 39604 hydrochlorideCat. No. 0991 |
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Chemical Name: 1-[4-Amino-5-chloro-2-(3,5-dimethoxyphenyl)methyloxy]-3-[1-[2-methylsulphonylamino]ethyl]piperidin-4-yl]propan-1-one hydrochloride |
Biological Activity
A potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and α1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies.Licensing Information
Sold with the permission of Roche BioscienceCertificate of Analysis / Safety Data Sheet
References
Eglen et al (1995) Central 5-HT4 receptors TiPS 16 391. PMID: 8578609.
Hegde (1995) RS 39604: a potent, selective and orally active 5-HT4 receptor antagonist. Br.J.Pharmacol. 115 1087. PMID: 7582507.
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Keywords: RS 39604 hydrochloride, supplier, 5-HT4, antagonist, Serotonin, Receptors, 5-Hydroxytryptamine, RS39604, hydrochloride
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