R&D Systems Inc. Tocris Bioscience Boston Biochem

RS 39604 hydrochloride

Cat. No. 0991

RS 39604 hydrochloride C26H36ClN3O6S.HCl [167710-87-4]

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Chemical Name: 1-[4-Amino-5-chloro-2-(3,5-dimethoxyphenyl)methyloxy]-3-[1-[2-methylsulphonylamino]ethyl]piperidin-4-yl]propan-1-one hydrochloride

Biological Activity

A potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and α1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies.

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data

M.Wt:
590.56
Formula:
C26H36ClN3O6S.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
167710-87-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
Safety Data Sheet: View Safety Data Sheet

References

Eglen et al (1995) Central 5-HT4 receptors TiPS 16 391. PMID: 8578609.

Hegde (1995) RS 39604: a potent, selective and orally active 5-HT4 receptor antagonist. Br.J.Pharmacol. 115 1087. PMID: 7582507.

If you know of a relevant citation for this product please let us know.

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Keywords: RS 39604 hydrochloride, supplier, 5-HT4, antagonist, Serotonin, Receptors, 5-Hydroxytryptamine, RS39604, hydrochloride

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