Cat. No. 2078
Chemical Name: (RS)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione
Biological ActivitySelective and potent GluR5-subunit containing kainate receptor antagonist (apparent KD = 1.09 mM). Displays ~ 90-fold selectivity over AMPA receptors and recombinant human GluR6- and KA2-containing kainate receptors. Has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibres. Active enantiomer UBP 302 (Cat. No. 2078) available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
More et al (2004) Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. Neuropharmacology 47 46. PMID: 15165833.
Dolman et al (2005) Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. J.Med.Chem. 48 7867. PMID: 16302825.
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Keywords: UBP 296, supplier, Selective, potent, kainate, antagonists, selective, GluR5-containing, receptors, Glutamate, Kainate, Receptors, iGluR, Ionotropic, UBP296
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