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Y-27152

Cat. No. 2077

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Chemical Name: N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide

Biological Activity

Prodrug of the K_ir6 (K_ATP) channel opener Y-26763 (Cat. No. 2076). Inactive in vitro; fails to modify tension in contracted aortic rings at concentrations up to 1 mM. Produces long-lasting antihypertensive effects in vivo, with minimal tachycardia following oral administration in hypertensive animals.

Technical Data

M.Wt:

366.41

Formula:

C₂₁H₂₂N₂O₄

Solubility:

Soluble to 5 mM in ethanol with gentle warming and to 25 mM in DMSO

Purity:

>98 %

Storage:

Store at RT

CAS No:

127408-30-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Nakajima et al (1992) Y-27152, a long-acting K⁺ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J.Pharmacol.Exp.Ther. 261 730. PMID: 1578381.

Fukunari et al (1997) Y-26763 protects the canine heart from a stunning injury through opening of the K_ATP channels. Eur.J.Pharmacol. 323 197. PMID: 9128839.

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