Cat. No. 2077
Chemical Name: N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hy
Biological ActivityProdrug of the Kir6 (KATP) channel opener Y-26763 (Cat. No. 2076). Inactive in vitro; fails to modify tension in contracted aortic rings at concentrations up to 1 mM. Produces long-lasting antihypertensive effects in vivo, with minimal tachycardia following oral administration in hypertensive animals.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Nakajima et al (1992) Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J.Pharmacol.Exp.Ther. 261 730. PMID: 1578381.
Fukunari et al (1997) Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels. Eur.J.Pharmacol. 323 197. PMID: 9128839.
If you know of a relevant citation for this product please let us know.
Keywords: Y-27152, supplier, Prodrug, KATP, channels, openers, Y-26763, orally, active, vivo, potassium, KIR, Inward, Rectifier, K+, Kir6
Find multiple products by catalog number
New Products in this Area
Potent and selective TASK-1 channel blockerHMR 1556
Potent and selective Iks channel blockerNS 19504
Activator of BKCa (KCa1.1) channelsTRAM 39
Potent KCa3.1 blocker
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.