Cat. No. 2077

Y-27152 C21H22N2O4 [127408-30-4]

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Chemical Name: N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide

Biological Activity

Prodrug of the Kir6 (KATP) channel opener Y-26763 (Cat. No. 2076). Inactive in vitro; fails to modify tension in contracted aortic rings at concentrations up to 1 mM. Produces long-lasting antihypertensive effects in vivo, with minimal tachycardia following oral administration in hypertensive animals.

Technical Data

Soluble to 5 mM in ethanol with gentle warming and to 25 mM in DMSO
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Nakajima et al (1992) Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J.Pharmacol.Exp.Ther. 261 730. PMID: 1578381.

Fukunari et al (1997) Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels. Eur.J.Pharmacol. 323 197. PMID: 9128839.

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View Related Products by Product Action

Keywords: Y-27152, supplier, Prodrug, KATP, channels, openers, Y-26763, orally, active, vivo, potassium, KIR, Inward, Rectifier, K+, Kir6, Inward Rectifier Potassium (Kir) Channel Activators

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