SKF 83959 hydrobromide
Cat. No. 2074
Chemical Name: 6-Chloro-2,3,4,5-tetrahydro-3-methy
Biological ActivityDopamine D1-like receptor partial agonist (Ki values are 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively). May act as an antagonist in vivo, producing anti-Parkinsonian effects and antagonizing the behavioral effects of cocaine. Shown to potentiate agonist binding of the σ1 receptor.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Platt et al (2000) Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434. J.Pharmacol.Exp.Ther. 293 1017. PMID: 10869406.
Cools et al (2002) SKF 83959 is an antagonist of dopamine D1-like receptors in the prefrontal cortex and nucleus accumbens: a key to its antiparkinsonian effect in animals? Neuropharmacology 42 237. PMID: 11804620.
Neumeyer et al (2003) Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines. Eur.J.Pharmacol. 474 137. PMID: 12921854.
Guo et al (2013) SKF83959 is a potent allosteric modulator of sigma-1 receptor. Mol.Pharmacol. 83 577. PMID: 23295385.
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Keywords: SKF 83959 hydrobromide, supplier, D1-like, partial, agonists, Dopamine, D1, Receptors, D5, dopaminergic, SKF83959, hydrobromide
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High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist
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