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cis-ACPDCat. No. 0186 |
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Chemical Name: (±)-1-Aminocyclopentane-cis-1,3-dicarboxylic acid |
Biological Activity
1:1 mixture of (1R,3R)- and (1S,3S)-ACPD. Potent NMDA receptor agonist and selective group II mGluR agonist (EC50 values are 13, 50, >300 and >300 μM at mGluR2, mGluR4, mGluR1 and mGluR5 respectively). Exhibits proconvulsant activity in vivo. (±)-trans-ACPD (Cat. No. 0187) and (1S,3R)-ACPD (Cat. No. 0284) also available.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
References
Schoepp et al (1991) In vitro and in vivo pharmacology of trans- and cis-(±)-1-amino-1,3-cyclopentanedicarboxylic acid: Dissociation of metabotropic and ionotropic excitatory amino acid receptor effects. J.Neurochem. 56 1789. PMID: 1849553.
Sunter et al (1991) Actions of the four isomers of 1-aminocyclopentane-1,3-dicarboxylate (ACPD) in the hemisected spinal cord of the neonatal rat. Br.J.Pharmacol. 104 337P.
Conti et al (2002) Synthesis and pharmacology of 3-hydroxy-Δ2-isoxazoline-cyclopentane analogues of glutamic acid. Farmaco 57 889. PMID: 12484537.
If you know of a relevant citation for this product please let us know.
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Keywords: cis-ACPD, supplier, Potent, NMDA, agonists, group, II, mGluR, Selective, potent, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, mGlur, Group, mGlu2, mGlu3, mGluR2, mGluR3, Metabotropic
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