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Aminopurvalanol ACat. No. 2072 |
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Alternative Name: NG 97 Chemical Name: (2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol |
Biological Activity
Cell-permeable cyclin-dependent kinase inhibitor. IC50 values are 0.033, 0.033, 0.028 and 0.020 μM for cdk1/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5/p35 respectively. Inhibits ERK1 (IC50 = 12.0 μM) and ERK2 (IC50 = 3.1 μM) and is 3000-fold selective over a range of other protein kinases (IC50 > 100 μM). Arrests cell cycle at G2/M boundary (IC50 = 1.25 μM), and induces apoptosis at concentrations > 10 μM.Licensing Information
Sold under license from the Regents of the University of CaliforniaCertificate of Analysis / Safety Data Sheet
References
Chang et al (1999) Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors. Chem.Biol. 6 361. PMID: 10375538.
Rosiana et al (1999) A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts. Proc.Natl.Acad.Sci.USA 96 4797.
Knockaert et al (2000) Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors. Chem.Biol. 7 411. PMID: 10873834.
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Keywords: Aminopurvalanol A, supplier, Cyclin-dependent, protein, kinases, inhibitors, Cdk, AminopurvalanolA, NG97
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