N-Acetyl-L-leucyl-L-leucyl-L-methional

Cat. No. 0384

N-Acetyl-L-leucyl-L-leucyl-L-methional C19H35N3O4S [136632-32-1]

Price and Availability

For N-Acetyl-L-leucyl-L-leucyl-L-methional pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Biological Activity

Very potent inhibitor of cathepsin L (Ki = 0.6 nM) and the strongest inhibitor of cathepsin B (Ki = 100 nM) amongst the peptide aldehydes. Also inhibits processing of malaria aspartic hemoglobinases plasmepsins I and II in vitro.

Technical Data

M.Wt:
401.56
Formula:
C19H35N3O4S
Solubility:
Soluble to 10 mM in ethanol and to 100 mM in DMSO
Storage:
Store at -20°C
CAS No:
136632-32-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Sasaki et al (1990) Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins. J.Enzyme Inhib. 3 195. PMID: 2079636.

Francis et al (1997) Biosynthesis and maturation of the malaria aspartic hemogloninases plasmepsins I and II. J.Biol.Chem. 272 14961. PMID: 9169469.

If you know of a relevant citation for this product please let us know.

Keywords: N-Acetyl-L-leucyl-L-leucyl-L-methional, supplier, Cathepsin, L, B, inhibitors, Proteinases, Proteases, Acetylleucylleucylmethional

Quick Order

Find multiple products by catalog number

divider line

New Product E-alerts

Sign up for email updates from Tocris

e-alerts

Enter your email address below to sign up to receive our email updates:

divider line

New Products in this Area

PR 619

Broad spectrum DUB inhibitor

TC-E 5007

Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor

SD 2590 hydrochloride

Potent MMP inhibitor

Aliskiren hemifumarate

Potent renin inhibitor; antihypertensive

Sign-up for new product e-alerts
divider line

Bio-Techne Events

EMBO 2015

The 6th EMBO Meeting 2015

September 5 - 8, 2015

Birmingham, UK