Cat. No. 0384

N-Acetyl-L-leucyl-L-leucyl-L-methional C19H35N3O4S [136632-32-1]

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Biological Activity

Very potent inhibitor of cathepsin L (Ki = 0.6 nM) and the strongest inhibitor of cathepsin B (Ki = 100 nM) amongst the peptide aldehydes. Also inhibits processing of malaria aspartic hemoglobinases plasmepsins I and II in vitro.

Technical Data

Soluble to 10 mM in ethanol and to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Sasaki et al (1990) Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins. J.Enzyme Inhib. 3 195. PMID: 2079636.

Francis et al (1997) Biosynthesis and maturation of the malaria aspartic hemogloninases plasmepsins I and II. J.Biol.Chem. 272 14961. PMID: 9169469.

If you know of a relevant citation for this product please let us know.

Keywords: N-Acetyl-L-leucyl-L-leucyl-L-methional, supplier, Cathepsin, L, B, inhibitors, Proteinases, Proteases, Acetylleucylleucylmethional

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