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N-Acetyl-L-leucyl-L-leucyl-L-methional

Cat. No. 0384

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Biological Activity

Very potent inhibitor of cathepsin L (K_i = 0.6 nM) and the strongest inhibitor of cathepsin B (K_i = 100 nM) amongst the peptide aldehydes. Also inhibits processing of malaria aspartic hemoglobinases plasmepsins I and II in vitro.

Technical Data

M.Wt:

401.56

Formula:

C₁₉H₃₅N₃O₄S

Solubility:

Soluble to 10 mM in ethanol and to 100 mM in DMSO

Storage:

Store at -20°C

CAS No:

136632-32-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Sasaki et al (1990) Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins. J.Enzyme Inhib. 3 195. PMID: 2079636.

Francis et al (1997) Biosynthesis and maturation of the malaria aspartic hemogloninases plasmepsins I and II. J.Biol.Chem. 272 14961. PMID: 9169469.

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