TRPV Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
TRPV1 Human TRPV1 NM_018727 Q8NER1
Mouse Trpv1 NM_001001445 Q704Y3
Rat Trpv1 NM_031982 O35433
TRPV2 Human TRPV2 NM_016113 Q9Y5S1
Mouse Trpv2 NM_011706 Q9WTR1
Rat Trpv2 NM_017207 Q9WUD2
TRPV3 Human TRPV3 NM_145068 Q8NET8
Mouse Trvp3 NM_145099 Q8K424
Rat Trpv3 NM_001025757 Q4QYD9
TRPV4 Human TRPV4 NM_021625 Q96Q92
Mouse Trpv4 NM_022017 Q9EPK8
Rat Trpv4 NM_023970 Q9ERZ8
TRPV5 Human TRPV5 NM_019841 Q9NQA5
Mouse Trpv5 NM_001007572 P69744
Rat Trpv5 NM_053787 Q9JIP0
TRPV6 Human TRPV6 NM_014274 Q9H1D0
Mouse Trpv6 NM_022413 Q91WD2
Rat Trpv6 NM_053686 Q9R186

TRPV Pharmacological Data

Receptor
(other names)
TRPV1
VR1, OTRPC1, Vanilloid/capsaicin receptor
TRPV2
VRL-1, OTRPC2, GRC
TRPV3
VRL-3
TRPV4
VRL-2, OTRPC4, VR-OAC, TRP12
TRPV5
OTRPC3, ECaC, ECaC1, CaT2
TRPV6
ECaC2, CaT1, CaT-L
Description Vanilloid receptor, noxious thermosensor, non-selective cation channel Noxious heat, noxious thermosensor, non-selective cation channel Warmth sensor, moderately selective Ca2+ channel Osmosensor, moderately selective Ca2+ channel Highly selective Ca2+ channel Highly selective Ca2+ channel
Receptor distribution Dorsal root and trigeminal ganglia, brain, spinal cord, pancreas, skin epithelial, bladder Dorsal root and trigeminal ganglia, brain, spinal cord, spleen, lung, mast cells, vascular smooth muscle Brain (cortex, thalamus), skin, hair follicles, tongue, stomach, spinal cord, superior clavicular, dorsal root and trigeminal ganglia Brain, liver, kidney, adipose tissue, heart, testis, salivary gland, trachea Intestine, kidney, placenta, brain Kidney, intestine
Tissue Function Pain sensation, vasodilation Thermal pain sensation, mast cell function Putative warm sensation Osmolarity sensing with thermal modulation Active Ca+ (re)absorption Active Ca2+ (re)absorption
Key Activators Capsaicin (0462)
Resiniferatoxin (1137)
Anandamide (1339)
Olvanil (0934)
Heat (threshold ~ 43oC)
Protons
Ethanol
Noxious heat (threshold =52oC)
IGF-1
Increasing temperature (~35oC) Reduced osmolarity None (constitutively active) None (constitutively active)
Antagonists Capsazepine (0464)
5'-Iodoresiniferatoxin (1362)
Ruthenium red (1439)
JNJ 17203212 (3361)
AMG 9810 (2316)
PIP2
Ruthenium red (1439)
SKF 963365 (1147)
La3+
Ruthenium red (1439) Ruthenium red (1439) Ruthenium red (1439)
La3+
Ruthenium red (1439)
La3+

References

Gunthorpe et al (2002) The diversity in the vanilloid (TRPV) receptor family of ion channels. TiPS 23 183. Clapham et al (2003) International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels; transient receptor potential channels. Pharmacol.Rev. 55 591. Alexander et al (2004) Guide to receptors and channels. Br.J.Pharmacol. 141 S89.