Tachykinin Receptor Data

Receptor Subtype NK1 NK2 NK3
Transduction Mechanism Activates Gq/11 Activates Gq/11 Activates Gq/11
Localization CNS (particularly the striatum, amygdala and some hypothalamic and thalamic nuclei), peripheral tissues Periphery (inflammatory cells and bronchial, gastrointestinal and urinary smooth muscle), limited expression in the CNS CNS (hippocampus, hypothalamus, substantia nigra, dorsal horn of the spinal cord), limited expression in the periphery
Preferred Endogenous Ligand Substance P (1156) > Neurokinin A (1152) > Neurokinin B (1582) Neurokinin A (1152) > Neurokinin B (1582) > Substance P (1156) Neurokinin B (1582) > Neurokinin A (1152) > Substance P (1156)
Selective Agonists GR 73632 (1669)
Hemokinin-1 (mouse) (1535)
[Sar9,Met(O2)11]-Substance P (1178)
Hemokinin-1 (human) (2576)
GR 64349 (1668)
[bAla8]-Neurokinin A(4-10) (1640)
[Lys5,MeLeu9,Nle10]-NKA(4-10) (3228)
Senktide (1068)
Selective Antagonists FK 888 (2400)
GR 82334 (1670)
L-732,138 (0868)
L-733,060 (1145)
RP 67580 (1635)
SDZ NKT 343 (2394)
GR 159897 (1274)
MDL 29,913 (1194)
MEN 10376 (1632)
MEN 10627
SB 218795 (1376)
SB 222200 (1393)