Prostanoid Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
EP1 Human PTGER1 NM_000955 P34995
Mouse Ptger1 NM_013641 P35375
Rat Ptger1 NM_013100 P70597
EP2 Human PTGER2 NM_000956 P43116
Mouse Pyry2 NM_008964 Q62053
Rat Ptger2 NM_031088 Q62928
EP3 Human PTGER3 NM_000957 P43115
Mouse Ptger3 NM_011196 P30557
Rat Ptger3 NM_012704 P34980
EP4 Human PTGER4 NM_000958 P35408
Mouse Ptger4 NM_008965 P32240
Rat Ptger4 NM_032076 P43114
TP Human TBXA2R NM_201636 P21731
Mouse Tbxa2r NM_009325 P30987
Rat Tbxa2r NM_017054 P34978
FP Human PTGFR NM_000959 P43088
Mouse Ptgfr NM_008966 P43117
Rat Ptgfr NM_013115 P43118
IP Human PTGIR NM_000960 P43119
Mouse Ptgir NM_008967 P43252
Rat Ptgir NM_001077644 P43253
DP Human PTGDR NM_000953 Q13258
Mouse Ptgdr NM_008962 P70263
Rat Ptgdr NM_022241 O35932

Pathway of Prostanoid Production

Pathway of Prostanoid Production

Prostanoid Receptor Pharmacological Data

Receptor Subtype EP1 EP2 EP3 EP4
Transduction Mechanism Gq → ↑ PI hydrolysis/Ca2+ Gs → ↑ cAMP Various (splice variants), mainly ↓ cAMP Gs → ↑ cAMP
Agonist Potencies PGE2 > PGF2, PGI2 > PGD2, TXA2 PGE2 > PGF2, PGI2 > PGD2, TXA2 PGE2 > PGF2, PGI2 > PGD2, TXA2 PGE2 > PGF2, PGI2 > PGD2, TXA2
Receptor Distribution Kidney, lung (mouse) Lung, placenta (human), uterus, lung, ileum, liver, thymus, spleen (mouse) Kidney, uterus, stomach, brain, thymus, lung, spleen (mouse), kidney, pancreas, uterus, heart, liver, testis, ovary (human) Ileum, thymus, spleen, lung, heart, stomach, uterus (mouse)
Tissue Functions GI contraction, tracheal contraction (guinea-pig), gastric fundus contraction Bronchodilatation (guinea-pig, cat), myometrial inhibition (human,baboon), vasodepression (cat, guinea-pig) Inhibition of gastric acid secretion (human, dog, rat), myometrial stimulation (human, cat,rat, hamster) Vasodilatation (dog), bronchodilatation (rat)

Receptor Subtype DP FP IP TP
Transduction Mechanism Gs → ↑ cAMP Gq → ↑ PI hydrolysis/Ca2+ Gs → ↑ cAMP
↑ PI hydrolysis/Ca2+
Gq → ↑ PI hydrolysis/Ca2+
Agonist Potencies PGD2 >> PGE2 > PGF2 > PGI2, TXA2 PGF2 > PGD2 > PGE2 > PGI2, TXA2 PGI2 >> PGD2 ,PGE2, PGF2 > TXA2 TXA2 = PGH2 >> PGD2, PGE2, PGF2, PGI2
Receptor Distribution Ileum, lung, stomach, uterus (mouse) Corpus luteum, kidney, lung, heart, stomach (mouse), overy, small intestine, prostate, spleen, testis (human) Aorta, lung, heart, kidney (human), thymus, spleen (mouse), NTS, dorsal horn (rat) Thymus, spleen, lung, kidney, heart, uterus (mouse)
Tissue Functions Inhibition of platelet aggregation Luteolysis Vasodepression, inhibition of platelet aggregation Vaso- and bronchoconstriction, platelet aggregation, myometrial stimulation

References

IUPHAR Compendium of receptor characterization and classification. (2000) 2nd Edition. IUPHAR Media. Breyer et al (2001) Prostanoid receptors: subtypes and signaling. Ann.Rev.Pharmacol.Toxicol. 41 661.