Properties of Voltage-Gated Sodium Channels

Location Subtype TTX Sensitive? Conductance (pS)
Brain I, II, IIA, III, VI Yes 2.5-25
Skeletal muscle μ1 Yes 2.5-25
Sympathetic ganglia PN1 Yes 6.3-10.7
Heart h1 No (IC50 6 μM) 2.5-25
Dorsal root ganglia PN3/SNS No (IC50 ~ 60 μM) 3.4-6.3


Catterall (1992) Cellular and molecular biology of voltage-gated sodium channels. Physiol.Rev. 72 S15. Gordon (1997) Sodium channels as targets for neurotoxins. Mode of action and interaction of neurotoxins with receptor sites on sodium channels. Toxins and Signal Transduction. Eds. Gutman and Lazarovici, pp119-153, Harwood Academic Publishers.