Properties of Imidazoline Receptors

Receptor I1 I2 I3
Location Lateral reticular nucleus, locus ceruleus, kidney, platelets, pancreas Interpeduncular and arcuate nuclei, pineal gland, liver, kidney, heart, striated muscle, MAO Pancreatic β cells
Transduction Mechanism ↑ Diacylglycerol and arachidonic acid Unknown Unknown
Key Selective Ligands AGN 192403 (1072)
Clonidine (0690)
Rilmenidine (0790)
BU 239 (0726)
RS 45041-190 (0889)
2-BFI (0348)
KU14R (1131)
Putative Endogenous Ligands Agmatine (0842), Harmane (1132)