Glucagon and Related Receptor Data

Receptor Subtype Glucagon GLP-1 GLP-2 Secretin GHRH GIP
G protein Gs Gs Gs Gs / Gq Gs Gs
Receptor Localisation Pancreas, liver, kidneys Pancreas, CNS, stomach, heart CNS, GI tract Pancreas, GI tract, CNS Anterior pituitary, placenta, kidney Pancreas, CNS
Tissue Functions Glucoregulation; controls glycogenolysis and gluconeogenesis via regulation of insulin secretion Glucoregulation; stimulates insulin secretion and suppresses glucagon secretion Maintains growth and absorptive function of the intestinal mucosal villus epithelium Regulates pancreatic exocrine and gastric secretions Regulates pituitary growth hormone synthesis and secretion Glucoregulation; potentiates insulin secretion
Selective Products L-168,049 (2311)
Glucagon (1-29) amide (2216)
Glucagon-like peptide 1 (7-36) amide (2082)
Glucagon-like peptide 1 (1-37) (1851)
Exendin-4 (1933)
Exendin-3 (9-39) amide (2081)
GLP-1 (9-36) amide (3266)
GLP-2 (human) (2258)
GLP-2 (rat) (2259)
Secretin (human) (1918)
Secretin (rat) (1919)
GRF (ovine) GIP (1-39) (2257)
GIP (human) (2084)


Brubaker and Drucker (2002) Structure-function of the glucagon receptor family of G protein-coupled recptors; the glucagon, GIP, GLP-1, and GLP-2 receptors. Receptors Channels 8 179. Mayo et al (2003) International union of pharmacology. XXXV. The glucagon receptor family. Pharmacol.Rev. 55 167. Alexander et al (2008) Guide to receptors and channels (GRAC). Br.J.Pharmacol. 153 S1-209.