Glutamate Transporter Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
EAAT1 Human SLC1A3 NM_004172 P43003
Mouse Slc1a3 NM_148938 P56564
Rat Slc1a3 NM_019225 P24942
EAAT2 Human SLC1A2 NM_004171 P43004
Mouse Slc1a2 NM_001077514 P43006
Rat Slc1a2 NM_017215 Q91ZA9
EAAT3 Human SLC1A1 NM_004170 P43005
Mouse Slc1a1 NM_009199 P51906
Rat Slc1a1 NM_013032 P51907
EAAT4 Human SLC1A6 NM_005071 P48664
Mouse Slc1a6 NM_009200 O35544
Rat Slc1a6 NM_032065 O35921
EAAT5 Human SLC1A7 NM_006671 O00341
Mouse Slc1a7 NM_146255 Q8JZR4
Rat Slc1a7 NM_001108973 XP_345560

Properties of Glutamate Transporters

Subtype EAAT1 EAAT2 EAAT3 EAAT4 EAAT5
Primary Distribution Cerebellar glia Forebrain glia Cortical neurons Cerebellar Purkinje neurons Retina
Selected Inhibitors Ki (μM)
cis-ACBD (0271)1 170 680 230 - -
Dihydrokainic acid (0111) > 30002 232 > 30002 - -
L-(-)-threo-3-Hydroxyaspartic acid (0183)1 11 19 14 - -
(±)-threo-3-Methylglutamic acid (0811) 1600 (IC50)3 90 (IC50)3 1080 (IC50)3 109 (IC50)3 -
L-trans-2,4-PDC (0298) 791 81 611 - -
DL-TBOA (1223) 70 (IC50)4 6 (IC50)4 6 (IC50)4 4.45 3.25

References

  1. Jensen and Bauner-Osborne (2004) Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescense-based membrane potential assay. Biochem.Pharmacol. 67 2115.
  2. Arriza et al (1994) Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J.Neurosci. 14 5559.
  3. Eliasof et al (2001) Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems. J.Neurochem. 77 550.
  4. Jabaudon et al (1999) Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin. Proc.Natl.Acad.Sci.USA 96 8733.
  5. Shigeri et al (2001) Effects of threo-β-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5). J.Neurochem. 79 298.