Properties of Adenylyl Cyclases

Subtype Endogenous Activators Endogenous Inhibitors
AC1 Ca2+/Calmodulin
PKC-evoked phosphorylation
Gαi
AC2 Gβγ
PKC-evoked phosphorylation
-
AC3 Ca2+/Calmodulin
PKC-evoked phosphorylation
Gαi
CaMKII-evoked phosphorylation
AC4 Gβγ PKC-evoked phosphorylation
AC5 PKC-evoked phosphorylation Gαi
Ca2+
PKA-evoked phosphorylation
AC6 - Gαi
Ca2+
PKA-evoked phosphorylation
PKC-evoked phosphorylation
AC7 PKC-evoked phosphorylation -
AC8 Ca2+ -
AC9 - Ca2+/calcineurin

References

Alexander et al (2008) Guide to receptors and channels (GRAC) 3rd edn. Br.J.Pharmacol. 153 S176.