CRF Receptor Data

Receptor Subtype CRF1 CRF2a CRF2b
Transduction Mechanism Activates Gs Activates Gs Activates Gs

Key Compounds Ki (nM)
Agonists CRF (human, rat) (1151)
Urocortin (rat) (1605)
Sauvagine (1609)
Stressin I (1608)
11
13
9.4
1.5
44
1.5
9.9
224
38
0.97
3.8
224
Antagonists Astressin (1606)
α-helical CRF 9-41 (1184)
NBI 27914 (1591)
CP 154526 (2779)
CP 376395 (3212)
K 41498 (2070)
2
17
2
2.7
12
425
1.5
5
> 10000
> 10000
> 10000
0.66
1
0.97
-
> 10000
> 10000
0.62

References

Perrin and Vale (1999) Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 885 312. Maciejewski-Lenoir et al (200) Selective impairment of corticotropin-releasing factor1 (CRF1) receptor-mediated function using CRF coupled to saporin. Endocrinology 141 498.