Properties of ATPases

Type P F V
Substances Transported H+, Na+, K+, Ca2+ H+ only H+ only
Structural and Functional Features Large catalytic α-subunits become phosphorylated during solute transport. β-subunits regulate transport Multiple TM and cytosolic subunits synthesize ATP on β-subunits, powered by movement of H+ down an electrochemical gradient Multiple TM and cytosolic subunits use energy released from ATP hydrolysis to pump H+ from cytosol to organelle lumen
Localization H+ pump: plasma membrane of plants, fungi, bacteria
Na+/K+ pump: plasma membrane of higher eukaryotes
H+/K+ pump: plasma membrane of gastric chief cells
Ca2+ pump: plasma membrane of eukaryotic cells
Ca2+ pump: sarcoplasmic reticulum membrane in muscle cells
Bacterial plasma membranes
Inner mitochondrial membrane
Thylakoid membrane of chloroplast
Vacuolar membranes in plants, yeast and other fungi
Endosomal and lyosomal membranes in eukaryotic cells
Plasma membrane of acid-secreting cells (e.g. osteoclasts)


Lodish et al (2000) Molecular Cell Biology. pp590. W.H.Freeman and Company.