Amyloid β (Aβ) peptides are the major component of amyloid plaques found in the brains of Alzheimer's patients. Aβ is formed from the progressive cleavage of amyloid precursor protein (APP) by β- and γ-secretase. Two Aβ peptides are formed from APP degradation.
More InfoStapled peptides are synthetic 'mini-proteins' that are locked into their bioactive α-helical secondary structure, so conferring high specificity, high potency and resistance to enzymatic degradation. They target protein-protein interactions (PPIs), opening up a range of targets that were previously considered to be undruggable.
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